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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage
|
|---|---|
| Published in |
Nature Communications, September 2017
|
| DOI | 10.1038/s41467-017-00737-8 |
| Pubmed ID | |
| Authors |
Chao Shan, Antonio E. Muruato, Brett W. Jagger, Justin Richner, Bruno T. D. Nunes, Daniele B. A. Medeiros, Xuping Xie, Jannyce G. C. Nunes, Kaitlyn M. Morabito, Wing-Pui Kong, Theodore C. Pierson, Alan D. Barrett, Scott C. Weaver, Shannan L. Rossi, Pedro F. C. Vasconcelos, Barney S. Graham, Michael S. Diamond, Pei-Yong Shi |
| Abstract |
Zika virus infection during pregnancy can cause congenital abnormities or fetal demise. The persistence of Zika virus in the male reproductive system poses a risk of sexual transmission. Here we demonstrate that live-attenuated Zika virus vaccine candidates containing deletions in the 3' untranslated region of the Zika virus genome (ZIKV-3'UTR-LAV) prevent viral transmission during pregnancy and testis damage in mice, as well as infection of nonhuman primates. After a single-dose vaccination, pregnant mice challenged with Zika virus at embryonic day 6 and evaluated at embryonic day 13 show markedly diminished levels of viral RNA in maternal, placental, and fetal tissues. Vaccinated male mice challenged with Zika virus were protected against testis infection, injury, and oligospermia. A single immunization of rhesus macaques elicited a rapid and robust antibody response, conferring complete protection upon challenge. Furthermore, the ZIKV-3'UTR-LAV vaccine candidates have a desirable safety profile. These results suggest that further development of ZIKV-3'UTR-LAV is warranted for humans.Zika virus infection can result in congenital disorders and cause disease in adults, and there is currently no approved vaccine. Here Shan et al. show that a single dose of a live-attenuated Zika vaccine prevents infection, testis damage and transmission to the fetus during pregnancy in different animal models. |
X Demographics
The data shown below were collected from the profiles of 28 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 29% |
| France | 2 | 7% |
| Brazil | 2 | 7% |
| Switzerland | 2 | 7% |
| Italy | 1 | 4% |
| Ecuador | 1 | 4% |
| Australia | 1 | 4% |
| Venezuela, Bolivarian Republic of | 1 | 4% |
| United Kingdom | 1 | 4% |
| Other | 2 | 7% |
| Unknown | 7 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 16 | 57% |
| Scientists | 8 | 29% |
| Science communicators (journalists, bloggers, editors) | 3 | 11% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 180 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 180 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 29 | 16% |
| Student > Ph. D. Student | 28 | 16% |
| Researcher | 26 | 14% |
| Student > Master | 24 | 13% |
| Student > Doctoral Student | 12 | 7% |
| Other | 24 | 13% |
| Unknown | 37 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 40 | 22% |
| Immunology and Microbiology | 29 | 16% |
| Agricultural and Biological Sciences | 25 | 14% |
| Medicine and Dentistry | 16 | 9% |
| Chemistry | 5 | 3% |
| Other | 22 | 12% |
| Unknown | 43 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 86. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2023.
All research outputs
#489,142
of 25,175,727 outputs
Outputs from Nature Communications
#8,314
of 55,628 outputs
Outputs of similar age
#10,275
of 324,521 outputs
Outputs of similar age from Nature Communications
#193
of 1,102 outputs
Altmetric has tracked 25,175,727 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 55,628 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.9. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,521 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 1,102 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.