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Mendeley readers
Attention Score in Context
| Title |
Sus1, a Functional Component of the SAGA Histone Acetylase Complex and the Nuclear Pore-Associated mRNA Export Machinery
|
|---|---|
| Published in |
Cell, January 2004
|
| DOI | 10.1016/s0092-8674(03)01025-0 |
| Pubmed ID | |
| Authors |
Susana Rodrı́guez-Navarro, Tamás Fischer, Ming-Juan Luo, Oreto Antúnez, Susanne Brettschneider, Johannes Lechner, Jose E. Pérez-Ortı́n, Robin Reed, Ed Hurt |
| Abstract |
Gene expression is a coordinated multistep process that begins with transcription and RNA processing in the nucleus followed by mRNA export to the cytoplasm for translation. Here we report the identification of a protein, Sus1, which functions in both transcription and mRNA export. Sus1 is a nuclear protein with a concentration at the nuclear pores. Biochemical analyses show that Sus1 interacts with SAGA, a large intranuclear histone acetylase complex involved in transcription initiation, and with the Sac3-Thp1 complex, which functions in mRNA export with specific nuclear pore proteins at the nuclear basket. DNA macroarray analysis revealed that Sus1 is required for transcription regulation. Moreover, chromatin immunoprecipitation showed that Sus1 is associated with the promoter of a SAGA-dependent gene during transcription activation. Finally, mRNA export is impaired in sus1 mutants. These data provide an unexpected connection between the SAGA histone acetylase complex and the mRNA export machinery. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Venezuela, Bolivarian Republic of | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 207 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 3 | 1% |
| United Kingdom | 3 | 1% |
| United States | 2 | <1% |
| Russia | 2 | <1% |
| Brazil | 1 | <1% |
| Switzerland | 1 | <1% |
| China | 1 | <1% |
| Spain | 1 | <1% |
| Poland | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 192 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 54 | 26% |
| Researcher | 45 | 22% |
| Student > Bachelor | 23 | 11% |
| Student > Master | 20 | 10% |
| Professor > Associate Professor | 17 | 8% |
| Other | 33 | 16% |
| Unknown | 15 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 110 | 53% |
| Biochemistry, Genetics and Molecular Biology | 68 | 33% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 1% |
| Computer Science | 3 | 1% |
| Immunology and Microbiology | 3 | 1% |
| Other | 5 | 2% |
| Unknown | 15 | 7% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 May 2023.
All research outputs
#7,304,457
of 26,017,215 outputs
Outputs from Cell
#12,049
of 17,318 outputs
Outputs of similar age
#30,373
of 147,517 outputs
Outputs of similar age from Cell
#46
of 80 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 17,318 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 59.7. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 147,517 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 80 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.