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Mendeley readers
Attention Score in Context
| Title |
EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation
|
|---|---|
| Published in |
Nature Cell Biology, August 2014
|
| DOI | 10.1038/ncb3031 |
| Pubmed ID | |
| Authors |
Hanane Lanaya, Anuradha Natarajan, Karin Komposch, Liang Li, Nicole Amberg, Lei Chen, Stefanie K. Wculek, Martina Hammer, Rainer Zenz, Markus Peck-Radosavljevic, Wolfgang Sieghart, Michael Trauner, Hongyang Wang, Maria Sibilia |
| Abstract |
Hepatocellular carcinoma (HCC) is a frequent cancer with limited treatment options and poor prognosis. Tumorigenesis has been linked with macrophage-mediated chronic inflammation and diverse signalling pathways, including the epidermal growth factor receptor (EGFR) pathway. The precise role of EGFR in HCC is unknown, and EGFR inhibitors have shown disappointing clinical results. Here we discover that EGFR is expressed in liver macrophages in both human HCC and in a mouse HCC model. Mice lacking EGFR in macrophages show impaired hepatocarcinogenesis, whereas mice lacking EGFR in hepatocytes unexpectedly develop more HCC owing to increased hepatocyte damage and compensatory proliferation. Mechanistically, following interleukin-1 stimulation, EGFR is required in liver macrophages to transcriptionally induce interleukin-6, which triggers hepatocyte proliferation and HCC. Importantly, the presence of EGFR-positive liver macrophages in HCC patients is associated with poor survival. This study demonstrates a tumour-promoting mechanism for EGFR in non-tumour cells, which could lead to more effective precision medicine strategies. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 174 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| India | 1 | <1% |
| United States | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 170 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 35 | 20% |
| Researcher | 29 | 17% |
| Student > Master | 23 | 13% |
| Student > Bachelor | 14 | 8% |
| Student > Doctoral Student | 13 | 7% |
| Other | 31 | 18% |
| Unknown | 29 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 39 | 22% |
| Medicine and Dentistry | 39 | 22% |
| Biochemistry, Genetics and Molecular Biology | 37 | 21% |
| Immunology and Microbiology | 10 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
| Other | 10 | 6% |
| Unknown | 35 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 58. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 August 2020.
All research outputs
#615,970
of 22,761,738 outputs
Outputs from Nature Cell Biology
#368
of 3,818 outputs
Outputs of similar age
#6,577
of 236,954 outputs
Outputs of similar age from Nature Cell Biology
#3
of 31 outputs
Altmetric has tracked 22,761,738 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,818 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.1. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 236,954 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.