Title |
Repair rather than segregation of damage is the optimal unicellular aging strategy
|
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Published in |
BMC Biology, August 2014
|
DOI | 10.1186/s12915-014-0052-x |
Pubmed ID | |
Authors |
Robert J Clegg, Rosemary J Dyson, Jan-Ulrich Kreft |
Abstract |
How aging, being unfavourable for the individual, can evolve is one of the fundamental problems of biology. Evidence for aging in unicellular organisms is far from conclusive. Some studies found aging even in symmetrically dividing unicellular species; others did not find aging in the same, or in different, unicellular species, or only under stress. Mathematical models suggested that segregation of non-genetic damage, as an aging strategy, would increase fitness. However, these models failed to consider repair as an alternative strategy or did not properly account for the benefits of repair. We used a new and improved individual-based model to examine rigorously the effect of a range of aging strategies on fitness in various environments. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 4 | 36% |
Unknown | 7 | 64% |
Demographic breakdown
Type | Count | As % |
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Scientists | 5 | 45% |
Members of the public | 4 | 36% |
Science communicators (journalists, bloggers, editors) | 1 | 9% |
Unknown | 1 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Israel | 1 | 2% |
Unknown | 64 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 16 | 25% |
Researcher | 15 | 23% |
Student > Bachelor | 6 | 9% |
Student > Master | 6 | 9% |
Student > Doctoral Student | 4 | 6% |
Other | 13 | 20% |
Unknown | 5 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 23 | 35% |
Biochemistry, Genetics and Molecular Biology | 16 | 25% |
Physics and Astronomy | 4 | 6% |
Mathematics | 3 | 5% |
Nursing and Health Professions | 2 | 3% |
Other | 7 | 11% |
Unknown | 10 | 15% |