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Synthesis, characterization, and bioactivity of carboxylic acid-functionalized titanium dioxide nanobelts

Overview of attention for article published in Particle and Fibre Toxicology, September 2014
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  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

policy
1 policy source
twitter
1 tweeter

Citations

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24 Dimensions

Readers on

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30 Mendeley
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Title
Synthesis, characterization, and bioactivity of carboxylic acid-functionalized titanium dioxide nanobelts
Published in
Particle and Fibre Toxicology, September 2014
DOI 10.1186/s12989-014-0043-7
Pubmed ID
Authors

Raymond F Hamilton, Nianqiang Wu, Chengcheng Xiang, Ming Li, Feng Yang, Michael Wolfarth, Dale W Porter, Andrij Holian

Abstract

BackgroundSurface modification strategies to reduce engineered nanomaterial (ENM) bioactivity have been used successfully in carbon nanotubes. This study examined the toxicity and inflammatory potential for two surface modifications (humic acid and carboxylation) on titanium nanobelts (TNB).MethodsThe in vitro exposure models include C57BL/6 alveolar macrophages (AM) and transformed human THP-1 cells exposed to TNB for 24 hrs in culture. Cell death and NLRP3 inflammasome activation (IL-1ß release) were monitored. Short term (4 and 24 hr) in vivo studies in C57BL/6, BALB/c and IL-1R null mice evaluated inflammation and cytokine release, and cytokine release from ex vivo cultured AM.ResultsBoth in vitro cell models suggest that the humic acid modification does not significantly affect TNB bioactivity, while carboxylation reduced both toxicity and NLRP3 inflammasome activation. In addition, short term in vivo exposures in both C57BL/6 and IL-1R null mouse strains demonstrated decreased markers of inflammation, supporting the in vitro finding that carboxylation is effective in reducing bioactivity. TNB instillations in IL-1R null mice demonstrated the critical role of IL-1ß in initiation of TNB-induced lung inflammation. Neutrophils were completely absent in the lungs of IL-1R null mice instilled with TNB for 24 hrs. However, the cytokine content of the IL-1R null mice lung lavage samples indicated that other inflammatory agents, IL-6 and TNF-¿ were constitutively elevated indicating a potential compensatory inflammatory mechanism in the absence of IL-1 receptors.ConclusionsTaken together, the data suggests that carboxylation, but not humic acid modification of TNB reduces, but does not totally eliminate bioactivity of TNB, which is consistent with previous studies of other long aspect ratio nanomaterials such as carbon nanotubes.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 20%
Student > Master 6 20%
Student > Doctoral Student 3 10%
Student > Bachelor 3 10%
Other 3 10%
Other 5 17%
Unknown 4 13%
Readers by discipline Count As %
Chemistry 6 20%
Pharmacology, Toxicology and Pharmaceutical Science 5 17%
Engineering 3 10%
Agricultural and Biological Sciences 3 10%
Medicine and Dentistry 2 7%
Other 5 17%
Unknown 6 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2015.
All research outputs
#3,515,141
of 12,521,989 outputs
Outputs from Particle and Fibre Toxicology
#110
of 370 outputs
Outputs of similar age
#53,941
of 201,447 outputs
Outputs of similar age from Particle and Fibre Toxicology
#2
of 5 outputs
Altmetric has tracked 12,521,989 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 370 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 201,447 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.