Title |
Molecular Epidemiology of NDM-1-Producing Enterobacteriaceae and Acinetobacter baumannii Isolates from Pakistan
|
---|---|
Published in |
Antimicrobial Agents and Chemotherapy, June 2014
|
DOI | 10.1128/aac.02425-14 |
Pubmed ID | |
Authors |
Anna L. Sartor, Muhammad W. Raza, Shahid A. Abbasi, Kathryn M. Day, John D. Perry, David L. Paterson, Hanna E. Sidjabat |
Abstract |
The molecular epidemiology of 66 NDM-producing isolates from 2 Pakistani hospitals was investigated, with their genetic relatedness determined using repetitive sequence-based PCR (Rep-PCR). PCR-based replicon typing and screening for antibiotic resistance genes encoding carbapenemases, other β-lactamases, and 16S methylases were also performed. Rep-PCR suggested a clonal spread of Enterobacter cloacae and Escherichia coli. A number of plasmid replicon types were identified, with the incompatibility A/C group (IncA/C) being the most common (78%). 16S methylase-encoding genes were coharbored in 81% of NDM-producing Enterobacteriaceae. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 2 | 3% |
Unknown | 61 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 22% |
Student > Master | 10 | 16% |
Student > Postgraduate | 7 | 11% |
Student > Bachelor | 6 | 10% |
Researcher | 6 | 10% |
Other | 9 | 14% |
Unknown | 11 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 21% |
Agricultural and Biological Sciences | 10 | 16% |
Immunology and Microbiology | 10 | 16% |
Biochemistry, Genetics and Molecular Biology | 7 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Other | 4 | 6% |
Unknown | 17 | 27% |