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Reduction of O-GlcNAcylation results in HIF-1α degradation. "OGT inhibition elicited a dose-dependent decrease in the levels of c-Myc protein but not c-Myc mRNA in prostate cell lines." https://t.co/Sla6q2WT3q
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"OGT inhibition elicited a dose-dependent decrease in the levels of c-Myc protein but not c-Myc mRNA in prostate cell lines." https://t.co/Sla6q2WT3q
3,585 followers
https://t.co/9rBvQaeBjR "EZH2 was found to activate c-Myc in breast cancer cells through the ERα and the Wnt pathways."
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https://t.co/9rBvQaeBjR "It is also possible that OGT by regulation of EZH2 may be involved in metabolic reprograming." "Polycomb group protein EZH2 is a direct upstream regulator of c-Myc oncogene." "c-Myc is one of the main regulators of cancer cell r