The Search for Anti-Inflammatory Drugs

Chapter 2 The History of the Discovery and Development of Cyclosporine (Sandimmune®)

Chapter 3 Discovery and Development of FK506 (Tacrolimus), A Potent Immunosuppressant of Microbial Origin

Chapter 4 Discovery of Sulindac, a Reversible Prodrug, as a Second-Generation Indomethacin

Chapter 5 The Discovery of Zileuton (Leutrol®)

Chapter 6 Discovery of Accolate™ (ICI 204,219), a Peptide Leukotriene Antagonist for Asthma

Chapter 7 Discovery of ZD2138, a Potent, Selective, Well-Tolerated, Nonredox Inhibitor of the Enzyme 5-Lipoxygenase

Chapter 8 Development of MK 0591: An Orally Active Leukotriene Biosynthesis Inhibitor with a Novel Mechanism of Action

Chapter 9 Discovery of BIRM 270: A New Class of Leukotriene Biosynthesis Inhibitors

Chapter 10 Discovery and Development of the Immunomodulatory Azaspiranes