Medea Gegia, Matthew J Magee, Russell R Kempker, Iagor Kalandadze, Tsira Chakhaia, Jonathan E Golub, Henry M Blumberg
Abstract
To assess the effect of tobacco smoking on the outcome of tuberculosis treatment in Tbilisi, Georgia.
We conducted a prospective cohort study of adults with laboratory-confirmed tuberculosis from May 2011 to November 2013. History of tobacco smoking was collected using a standardized questionnaire adapted from the global adult tobacco survey. We considered tuberculosis therapy to have a poor outcome if participants defaulted, failed treatment or died. We used multivariable regressions to estimate the risk of a poor treatment outcome.
Of the 591 tuberculosis patients enrolled, 188 (31.8%) were past smokers and 271 (45.9%) were current smokers. Ninety (33.2%) of the current smokers and 24 (18.2%) of the participants who had never smoked had previously been treated for tuberculosis (P < 0.01). Treatment outcome data were available for 524 of the participants, of whom 128 (24.4%) - including 80 (32.9%) of the 243 current smokers and 21 (17.2%) of the 122 individuals who had never smoked - had a poor treatment outcome. Compared with those who had never smoked, current smokers had an increased risk of poor treatment outcome (adjusted relative risk, aRR: 1.70; 95% confidence interval, CI: 1.00-2.90). Those who had ceased smoking more than two months before enrolment did not have such an increased risk (aRR: 1.01; 95% CI: 0.51-1.99).
There is a high prevalence of smoking among patients with tuberculosis in Georgia and smoking increases the risk of a poor treatment outcome.
Pharmacology, Toxicology and Pharmaceutical Science
6
3%
Other
18
10%
Unknown
48
27%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2018.
All research outputs
#8,783,469
of 25,986,827 outputs
Outputs from Bulletin of the World Health Organization
#83
of 286 outputs
Outputs of similar age
#97,944
of 279,406 outputs
Outputs of similar age from Bulletin of the World Health Organization
#8
of 11 outputs
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