Chapter title |
Evolutionary Conservation and Expression of Human RNA-Binding Proteins and Their Role in Human Genetic Disease.
|
---|---|
Chapter number | 1 |
Book title |
Systems Biology of RNA Binding Proteins
|
Published in |
Advances in experimental medicine and biology, January 2014
|
DOI | 10.1007/978-1-4939-1221-6_1 |
Pubmed ID | |
Book ISBNs |
978-1-4939-1220-9, 978-1-4939-1221-6
|
Authors |
Stefanie Gerstberger, Markus Hafner, Manuel Ascano, Thomas Tuschl, Gerstberger, Stefanie, Hafner, Markus, Ascano, Manuel, Tuschl, Thomas |
Editors |
Gene W. Yeo |
Abstract |
RNA-binding proteins (RBPs) are effectors and regulators of posttranscriptional gene regulation (PTGR). RBPs regulate stability, maturation, and turnover of all RNAs, often binding thousands of targets at many sites. The importance of RBPs is underscored by their dysregulation or mutations causing a variety of developmental and neurological diseases. This chapter globally discusses human RBPs and provides a brief introduction to their identification and RNA targets. We review RBPs based on common structural RNA-binding domains, study their evolutionary conservation and expression, and summarize disease associations of different RBP classes. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Sweden | 1 | <1% |
Italy | 1 | <1% |
Unknown | 129 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 28 | 21% |
Researcher | 23 | 17% |
Student > Master | 19 | 14% |
Student > Bachelor | 14 | 11% |
Student > Doctoral Student | 6 | 5% |
Other | 16 | 12% |
Unknown | 26 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 46 | 35% |
Agricultural and Biological Sciences | 32 | 24% |
Medicine and Dentistry | 11 | 8% |
Chemistry | 3 | 2% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
Other | 6 | 5% |
Unknown | 32 | 24% |