Title |
T-cell activation discriminates subclasses of symptomatic primary humoral immunodeficiency diseases in adults
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Published in |
BMC Immunology, March 2014
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DOI | 10.1186/1471-2172-15-13 |
Pubmed ID | |
Authors |
Marie-Quitterie Picat, Rodolphe Thiébaut, François Lifermann, Xavier Delbrel, Daniel Adoue, Linda Wittkop, Anne-Laure Fauchais, Patrick Rispal, Jean-François Moreau, Jean-François Viallard |
Abstract |
Symptomatic Primary Humoral Immunodeficiency Diseases (PHID) constitute a highly heterogeneous group of diseases characterized by a shared hypogammaglobulinemia, resulting in increased risk of recurrent or severe infections. Associations have been described with a variety of immunological abnormalities involving B and T-cell differentiation, T-cell activation and innate immunity. However, PHID discrimination remains based on B-lymphocyte abnormalities and other components of the immune system have not been sufficiently taken into account. We carried out unsupervised and supervised methods for classification in a cohort of 81 symptomatic PHID patients to evaluate the relative importance of 23 immunological parameters and to select relevant markers that may be useful for diagnosis and prognosis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | 4% |
Unknown | 22 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 17% |
Student > Master | 4 | 17% |
Other | 3 | 13% |
Researcher | 3 | 13% |
Student > Bachelor | 2 | 9% |
Other | 4 | 17% |
Unknown | 3 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 6 | 26% |
Medicine and Dentistry | 6 | 26% |
Immunology and Microbiology | 4 | 17% |
Sports and Recreations | 2 | 9% |
Unknown | 5 | 22% |