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Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s disease

Overview of attention for article published in Molecular Neurodegeneration, September 2014
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2 X users
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1 Facebook page

Citations

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133 Dimensions

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194 Mendeley
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Title
Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s disease
Published in
Molecular Neurodegeneration, September 2014
DOI 10.1186/1750-1326-9-33
Pubmed ID
Authors

Véréna Landel, Kévin Baranger, Isabelle Virard, Béatrice Loriod, Michel Khrestchatisky, Santiago Rivera, Philippe Benech, François Féron

Abstract

The 5XFAD early onset mouse model of Alzheimer's disease (AD) is gaining momentum. Behavioral, electrophysiological and anatomical studies have identified age-dependent alterations that can be reminiscent of human AD. However, transcriptional changes during disease progression have not yet been investigated. To this end, we carried out a transcriptomic analysis on RNAs from the neocortex and the hippocampus of 5XFAD female mice at the ages of one, four, six and nine months (M1, M4, M6, M9).

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 194 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
Japan 1 <1%
Unknown 191 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 47 24%
Researcher 40 21%
Student > Master 18 9%
Student > Bachelor 17 9%
Student > Doctoral Student 11 6%
Other 33 17%
Unknown 28 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 50 26%
Neuroscience 43 22%
Biochemistry, Genetics and Molecular Biology 24 12%
Medicine and Dentistry 15 8%
Pharmacology, Toxicology and Pharmaceutical Science 9 5%
Other 16 8%
Unknown 37 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2014.
All research outputs
#17,302,400
of 25,394,764 outputs
Outputs from Molecular Neurodegeneration
#849
of 977 outputs
Outputs of similar age
#150,024
of 250,385 outputs
Outputs of similar age from Molecular Neurodegeneration
#11
of 14 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 977 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.6. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,385 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.