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Mesenchymal Stem Cell Therapy Promotes Corneal Allograft Survival in Rats by Local and Systemic Immunomodulation

Overview of attention for article published in American Journal of Transplantation, August 2014
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Mentioned by

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3 tweeters

Citations

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35 Dimensions

Readers on

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42 Mendeley
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Title
Mesenchymal Stem Cell Therapy Promotes Corneal Allograft Survival in Rats by Local and Systemic Immunomodulation
Published in
American Journal of Transplantation, August 2014
DOI 10.1111/ajt.12828
Pubmed ID
Authors

O. Treacy, L. O'Flynn, A. E. Ryan, M. Morcos, P. Lohan, S. Schu, M. Wilk, G. Fahy, M. D. Griffin, M. Nosov, T. Ritter

Abstract

Mesenchymal stem cells (MSCs) are being investigated extensively due to their ability to dampen immune responses. Here, we tested the ability of MSCs from three distinct sources to prolong rat corneal allograft survival. A fully allogeneic rat cornea transplant model (DA to LEW) was used. Recipient rats received 1 × 10(6) MSCs (syn [LEW], allo [DA] or third-party [Wistar Furth]) intravenously 7 days before transplantation and again on the day of transplantation (day 0). A high percentage of untreated and syn-MSC treated allografts were rejected (80% and 100%, respectively). Preactivation of syn-MSCs with interferon gamma also failed to prolong allograft survival. Conversely, corneal allograft survival was significantly prolonged in allo-MSC treated (90%) and third-party MSC treated (80%) allograft recipients. Flow cytometric analysis revealed less infiltrating natural killer T cells in corneas of both allo- and third-party MSC treated animals, coupled with a higher proportion of splenic CD4+Foxp3+ regulatory T cells, compared to controls. In the case of allo- and third-party MSCs, results from a delayed-type hypersensitivity assay clearly showed that hypo-responsiveness was specific for corneal donor-associated allo-antigens. Thus, allo- and third-party MSC treatment prolongs corneal allograft survival by suppressing peripheral immune responses and promoting an intragraft immunoregulatory milieu.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ireland 1 2%
Unknown 41 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 19%
Student > Bachelor 7 17%
Student > Master 6 14%
Other 4 10%
Student > Ph. D. Student 4 10%
Other 4 10%
Unknown 9 21%
Readers by discipline Count As %
Medicine and Dentistry 10 24%
Agricultural and Biological Sciences 6 14%
Biochemistry, Genetics and Molecular Biology 5 12%
Immunology and Microbiology 3 7%
Chemistry 1 2%
Other 8 19%
Unknown 9 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 October 2014.
All research outputs
#8,438,477
of 14,003,034 outputs
Outputs from American Journal of Transplantation
#2,218
of 3,292 outputs
Outputs of similar age
#96,489
of 202,942 outputs
Outputs of similar age from American Journal of Transplantation
#37
of 75 outputs
Altmetric has tracked 14,003,034 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,292 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 202,942 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 75 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.