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Artificial sweeteners induce glucose intolerance by altering the gut microbiota

Overview of attention for article published in Nature, September 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Citations

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1182 Dimensions

Readers on

mendeley
3675 Mendeley
citeulike
16 CiteULike
Title
Artificial sweeteners induce glucose intolerance by altering the gut microbiota
Published in
Nature, September 2014
DOI 10.1038/nature13793
Pubmed ID
Authors

Jotham Suez, Tal Korem, David Zeevi, Gili Zilberman-Schapira, Christoph A. Thaiss, Ori Maza, David Israeli, Niv Zmora, Shlomit Gilad, Adina Weinberger, Yael Kuperman, Alon Harmelin, Ilana Kolodkin-Gal, Hagit Shapiro, Zamir Halpern, Eran Segal, Eran Elinav

Abstract

Non-caloric artificial sweeteners (NAS) are among the most widely used food additives worldwide, regularly consumed by lean and obese individuals alike. NAS consumption is considered safe and beneficial owing to their low caloric content, yet supporting scientific data remain sparse and controversial. Here we demonstrate that consumption of commonly used NAS formulations drives the development of glucose intolerance through induction of compositional and functional alterations to the intestinal microbiota. These NAS-mediated deleterious metabolic effects are abrogated by antibiotic treatment, and are fully transferrable to germ-free mice upon faecal transplantation of microbiota configurations from NAS-consuming mice, or of microbiota anaerobically incubated in the presence of NAS. We identify NAS-altered microbial metabolic pathways that are linked to host susceptibility to metabolic disease, and demonstrate similar NAS-induced dysbiosis and glucose intolerance in healthy human subjects. Collectively, our results link NAS consumption, dysbiosis and metabolic abnormalities, thereby calling for a reassessment of massive NAS usage.

Twitter Demographics

The data shown below were collected from the profiles of 3,819 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 3,675 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 55 1%
Canada 12 <1%
Germany 10 <1%
United Kingdom 10 <1%
Brazil 8 <1%
Netherlands 7 <1%
Spain 7 <1%
Japan 6 <1%
Chile 5 <1%
Other 56 2%
Unknown 3499 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 606 16%
Student > Ph. D. Student 582 16%
Student > Bachelor 581 16%
Student > Master 528 14%
Other 232 6%
Other 712 19%
Unknown 434 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 1044 28%
Medicine and Dentistry 644 18%
Biochemistry, Genetics and Molecular Biology 399 11%
Nursing and Health Professions 247 7%
Immunology and Microbiology 134 4%
Other 624 17%
Unknown 583 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 4697. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2022.
All research outputs
#728
of 21,429,365 outputs
Outputs from Nature
#70
of 88,046 outputs
Outputs of similar age
#3
of 222,011 outputs
Outputs of similar age from Nature
#2
of 997 outputs
Altmetric has tracked 21,429,365 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 88,046 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 97.6. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 222,011 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 997 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.