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Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease

Overview of attention for article published in Respiratory Research, September 2014
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (56th percentile)

Mentioned by

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4 tweeters
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1 Facebook page

Citations

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36 Dimensions

Readers on

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82 Mendeley
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Title
Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease
Published in
Respiratory Research, September 2014
DOI 10.1186/s12931-014-0113-2
Pubmed ID
Authors

Jin Hwa Lee, Michael H Cho, Craig P Hersh, Merry-Lynn N McDonald, James D Crapo, Per S Bakke, Amund Gulsvik, Alejandro P Comellas, Christine H Wendt, David A Lomas, Victor Kim, Edwin K Silverman

Abstract

BackgroundChronic bronchitis (CB) is one of the classic phenotypes of COPD. The aims of our study were to investigate genetic variants associated with COPD subjects with CB relative to smokers with normal spirometry, and to assess for genetic differences between subjects with CB and without CB within the COPD population.MethodsWe analyzed data from current and former smokers from three cohorts: the COPDGene Study; GenKOLS (Bergen, Norway); and the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE). CB was defined as having a cough productive of phlegm on most days for at least 3 consecutive months per year for at least 2 consecutive years. CB COPD cases were defined as having both CB and at least moderate COPD based on spirometry. Our primary analysis used smokers with normal spirometry as controls; secondary analysis was performed using COPD subjects without CB as controls. Genotyping was performed on Illumina platforms; results were summarized using fixed-effect meta-analysis.ResultsFor CB COPD relative to smoking controls, we identified a new genome-wide significant locus on chromosome 11p15.5 (rs34391416, OR¿=¿1.93, P¿=¿4.99¿×¿10-8) as well as significant associations of known COPD SNPs within FAM13A. In addition, a GWAS of CB relative to those without CB within COPD subjects showed suggestive evidence for association on 1q23.3 (rs114931935, OR¿=¿1.88, P¿=¿4.99¿×¿10-7).ConclusionsWe found genome-wide significant associations with CB COPD on 4q22.1 (FAM13A) and 11p15.5 (EFCAB4A, CHID1 and AP2A2), and a locus associated with CB within COPD subjects on 1q23.3 (RPL31P11 and ATF6). This study provides further evidence that genetic variants may contribute to phenotypic heterogeneity of COPD.Trial registrationClinicalTrials.gov NCT00608764, NCT00292552.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 1%
Brazil 1 1%
United Kingdom 1 1%
Canada 1 1%
Spain 1 1%
Unknown 77 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 17%
Professor 13 16%
Professor > Associate Professor 10 12%
Student > Bachelor 6 7%
Student > Ph. D. Student 6 7%
Other 20 24%
Unknown 13 16%
Readers by discipline Count As %
Medicine and Dentistry 32 39%
Agricultural and Biological Sciences 12 15%
Biochemistry, Genetics and Molecular Biology 10 12%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Neuroscience 2 2%
Other 8 10%
Unknown 15 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 December 2014.
All research outputs
#7,902,298
of 14,054,251 outputs
Outputs from Respiratory Research
#991
of 1,725 outputs
Outputs of similar age
#87,323
of 209,043 outputs
Outputs of similar age from Respiratory Research
#4
of 5 outputs
Altmetric has tracked 14,054,251 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,725 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 209,043 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one.