You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Mendeley readers
| Title |
TGF-β in pancreatic cancer initiation and progression: two sides of the same coin
|
|---|---|
| Published in |
Cell & Bioscience, August 2017
|
| DOI | 10.1186/s13578-017-0168-0 |
| Pubmed ID | |
| Authors |
Wei Shen, Guo-qing Tao, Yu Zhang, Bing Cai, Jian Sun, Zhi-qiang Tian |
| Abstract |
Pancreatic cancer is highly lethal malignant tumor with characterised rapid progression, invasiveness and resistance to radiochemotherapy. Transforming growth factor-β (TGF-β) signaling plays a dual role in both pro-tumorigenic and tumor suppressive of pancreatic cancer, depending on tumor stage and microenvironment. TGF-β signaling components alteration are common in pancreatic cancer, and its leading role in tumor formation and metastases has received increased attention. Many therapies have investigated to target TGF-β signaling in the preclinical and clinical setting. In this review, we highlight the dual roles of TGF-β and touch upon the perspectives on therapeutic target of TGF-β signaling in pancreatic cancer. |
Mendeley readers
The data shown below were compiled from readership statistics for 133 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 133 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 17% |
| Student > Master | 23 | 17% |
| Student > Bachelor | 18 | 14% |
| Student > Doctoral Student | 11 | 8% |
| Researcher | 8 | 6% |
| Other | 14 | 11% |
| Unknown | 36 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 42 | 32% |
| Medicine and Dentistry | 18 | 14% |
| Agricultural and Biological Sciences | 16 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
| Immunology and Microbiology | 4 | 3% |
| Other | 6 | 5% |
| Unknown | 42 | 32% |