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X Demographics
Mendeley readers
Attention Score in Context
| Title |
ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma
|
|---|---|
| Published in |
Cell Metabolism (Science Direct), October 2017
|
| DOI | 10.1016/j.cmet.2017.09.001 |
| Pubmed ID | |
| Authors |
Juan F. Linares, Thekla Cordes, Angeles Duran, Miguel Reina-Campos, Tania Valencia, Christopher S. Ahn, Elias A. Castilla, Jorge Moscat, Christian M. Metallo, Maria T. Diaz-Meco |
| Abstract |
Tumors undergo nutrient stress and need to reprogram their metabolism to survive. The stroma may play a critical role in this process by providing nutrients to support the epithelial compartment of the tumor. Here we show that p62 deficiency in stromal fibroblasts promotes resistance to glutamine deprivation by the direct control of ATF4 stability through its p62-mediated polyubiquitination. ATF4 upregulation by p62 deficiency in the stroma activates glucose carbon flux through a pyruvate carboxylase-asparagine synthase cascade that results in asparagine generation as a source of nitrogen for stroma and tumor epithelial proliferation. Thus, p62 directly targets nuclear transcription factors to control metabolic reprogramming in the microenvironment and repress tumorigenesis, and identifies ATF4 as a synthetic vulnerability in p62-deficient tumor stroma. |
X Demographics
The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 2 | 12% |
| Spain | 2 | 12% |
| United States | 2 | 12% |
| United Kingdom | 2 | 12% |
| Netherlands | 1 | 6% |
| Australia | 1 | 6% |
| Unknown | 7 | 41% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 10 | 59% |
| Members of the public | 6 | 35% |
| Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 125 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 22% |
| Researcher | 18 | 14% |
| Student > Master | 11 | 9% |
| Student > Postgraduate | 10 | 8% |
| Student > Bachelor | 9 | 7% |
| Other | 21 | 17% |
| Unknown | 29 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 59 | 47% |
| Agricultural and Biological Sciences | 17 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 5% |
| Medicine and Dentistry | 3 | 2% |
| Immunology and Microbiology | 3 | 2% |
| Other | 9 | 7% |
| Unknown | 28 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 70. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#611,474
of 25,382,440 outputs
Outputs from Cell Metabolism (Science Direct)
#652
of 3,170 outputs
Outputs of similar age
#13,025
of 330,919 outputs
Outputs of similar age from Cell Metabolism (Science Direct)
#24
of 58 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,170 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 74.0. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,919 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.