Title |
Nebulized perflubron and carbon dioxide rapidly dilate constricted airways in an ovine model of allergic asthma
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Published in |
Respiratory Research, September 2014
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DOI | 10.1186/s12931-014-0098-x |
Pubmed ID | |
Authors |
Tamer Y El Mays, Parichita Choudhury, Richard Leigh, Emmanuel Koumoundouros, Joanne Van der Velden, Grishma Shrestha, Cora A Pieron, John H Dennis, Francis HY Green, Ken J Snibson |
Abstract |
The low toxicity of perfluorocarbons (PFCs), their high affinity for respiratory gases and their compatibility with lung surfactant have made them useful candidates for treating respiratory diseases such as adult respiratory distress syndrome. We report results for treating acute allergic and non-allergic bronchoconstriction in sheep using S-1226 (a gas mixture containing carbon dioxide and small volumes of nebulized perflubron). The carbon dioxide, which is highly soluble in perflubron, was used to relax airway smooth muscle. |
X Demographics
Geographical breakdown
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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Demographic breakdown
Readers by professional status | Count | As % |
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Unspecified | 3 | 12% |
Student > Master | 3 | 12% |
Student > Bachelor | 3 | 12% |
Student > Doctoral Student | 2 | 8% |
Other | 2 | 8% |
Other | 6 | 23% |
Unknown | 7 | 27% |
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Unspecified | 3 | 12% |
Nursing and Health Professions | 2 | 8% |
Agricultural and Biological Sciences | 2 | 8% |
Environmental Science | 1 | 4% |
Other | 4 | 15% |
Unknown | 7 | 27% |