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Enzyme replacement therapy with idursulfase for mucopolysaccharidosis type II (Hunter syndrome)

Overview of attention for article published in Cochrane database of systematic reviews, January 2014
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (54th percentile)

Mentioned by

twitter
2 tweeters

Citations

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12 Dimensions

Readers on

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10 Mendeley
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Title
Enzyme replacement therapy with idursulfase for mucopolysaccharidosis type II (Hunter syndrome)
Published in
Cochrane database of systematic reviews, January 2014
DOI 10.1002/14651858.cd008185.pub3
Pubmed ID
Authors

da Silva EM, Strufaldi MW, Andriolo RB, Silva LA

Abstract

Mucopolysaccharidosis II, also known as Hunter syndrome, is a rare, X-linked disease caused by a deficiency of the lysosomal enzyme iduronate-2-sulfatase, which catalyses a step in the catabolism of glycosaminoglycans. The glycosaminoglycans accumulate within tissues affecting multiple organs and physiologic systems. The clinical manifestations include neurologic involvement, severe airways obstruction, skeletal deformities and cardiomyopathy. The disease has a variable age of onset and variable rate of progression. In those with severe disease, death usually occurs in the second decade of life, whereas those patients with less severe disease may survive into adulthood. Enzyme replacement therapy with intravenous infusions of idursulfase has emerged as a new treatment for mucopolysaccharidosis type II.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 3 30%
Student > Bachelor 2 20%
Student > Doctoral Student 2 20%
Student > Ph. D. Student 1 10%
Other 1 10%
Other 2 20%
Readers by discipline Count As %
Medicine and Dentistry 6 60%
Computer Science 1 10%
Biochemistry, Genetics and Molecular Biology 1 10%
Agricultural and Biological Sciences 1 10%
Immunology and Microbiology 1 10%
Other 1 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 February 2015.
All research outputs
#2,215,187
of 4,804,073 outputs
Outputs from Cochrane database of systematic reviews
#5,803
of 7,455 outputs
Outputs of similar age
#54,700
of 128,692 outputs
Outputs of similar age from Cochrane database of systematic reviews
#156
of 166 outputs
Altmetric has tracked 4,804,073 research outputs across all sources so far. This one has received more attention than most of these and is in the 51st percentile.
So far Altmetric has tracked 7,455 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.3. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 128,692 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 166 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.