Title |
Genome-Wide Association Study of L-Arginine and Dimethylarginines Reveals Novel Metabolic Pathway for Symmetric Dimethylarginine
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Published in |
Circulation: Genomic and Precision Medicine, September 2014
|
DOI | 10.1161/circgenetics.113.000264 |
Pubmed ID | |
Authors |
Nicole Lüneburg, Wolfgang Lieb, Tanja Zeller, Ming-Huei Chen, Renke Maas, Angela M Carter, Vanessa Xanthakis, Nicole L Glazer, Edzard Schwedhelm, Sudha Seshadri, Mohammad Arfan Ikram, William T Longstreth, Myriam Fornage, Inke R König, Christina Loley, Francisco M Ojeda, Arne Schillert, Thomas J Wang, Heinrich Sticht, Anja Kittel, Jörg König, Emelia J Benjamin, Lisa M Sullivan, Isabel Bernges, Maike Anderssohn, Andreas Ziegler, Christian Gieger, Thomas Illig, Christa Meisinger, H-Erich Wichmann, Philipp S Wild, Heribert Schunkert, Bruce M Psaty, Kerri L Wiggins, Susan R Heckbert, Nicholas Smith, Karl Lackner, Kathryn L Lunetta, Stefan Blankenberg, Jeanette Erdmann, Thomas Munzel, Peter J Grant, Ramachandran S Vasan, Rainer H Böger |
Abstract |
-Dimethylarginines (DMA) interfere with nitric oxide (NO) formation by inhibiting NO synthase (asymmetric dimethylarginine, ADMA) and L-arginine uptake into the cell (ADMA and symmetric dimethylarginine, SDMA). In prospective clinical studies ADMA has been characterized as a cardiovascular risk marker whereas SDMA is a novel marker for renal function and associated with all-cause mortality after ischemic stroke. The aim of the current study was to characterise the environmental and genetic contributions to inter-individual variability of these biomarkers. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 33% |
United States | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 52 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 19% |
Researcher | 7 | 13% |
Student > Bachelor | 6 | 12% |
Student > Doctoral Student | 5 | 10% |
Other | 5 | 10% |
Other | 14 | 27% |
Unknown | 5 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 31% |
Biochemistry, Genetics and Molecular Biology | 6 | 12% |
Nursing and Health Professions | 2 | 4% |
Agricultural and Biological Sciences | 2 | 4% |
Veterinary Science and Veterinary Medicine | 2 | 4% |
Other | 12 | 23% |
Unknown | 12 | 23% |