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Genome-Wide Association Study of L-Arginine and Dimethylarginines Reveals Novel Metabolic Pathway for Symmetric Dimethylarginine

Overview of attention for article published in Circulation: Genomic and Precision Medicine, September 2014
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3 X users

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48 Dimensions

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52 Mendeley
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Title
Genome-Wide Association Study of L-Arginine and Dimethylarginines Reveals Novel Metabolic Pathway for Symmetric Dimethylarginine
Published in
Circulation: Genomic and Precision Medicine, September 2014
DOI 10.1161/circgenetics.113.000264
Pubmed ID
Authors

Nicole Lüneburg, Wolfgang Lieb, Tanja Zeller, Ming-Huei Chen, Renke Maas, Angela M Carter, Vanessa Xanthakis, Nicole L Glazer, Edzard Schwedhelm, Sudha Seshadri, Mohammad Arfan Ikram, William T Longstreth, Myriam Fornage, Inke R König, Christina Loley, Francisco M Ojeda, Arne Schillert, Thomas J Wang, Heinrich Sticht, Anja Kittel, Jörg König, Emelia J Benjamin, Lisa M Sullivan, Isabel Bernges, Maike Anderssohn, Andreas Ziegler, Christian Gieger, Thomas Illig, Christa Meisinger, H-Erich Wichmann, Philipp S Wild, Heribert Schunkert, Bruce M Psaty, Kerri L Wiggins, Susan R Heckbert, Nicholas Smith, Karl Lackner, Kathryn L Lunetta, Stefan Blankenberg, Jeanette Erdmann, Thomas Munzel, Peter J Grant, Ramachandran S Vasan, Rainer H Böger

Abstract

-Dimethylarginines (DMA) interfere with nitric oxide (NO) formation by inhibiting NO synthase (asymmetric dimethylarginine, ADMA) and L-arginine uptake into the cell (ADMA and symmetric dimethylarginine, SDMA). In prospective clinical studies ADMA has been characterized as a cardiovascular risk marker whereas SDMA is a novel marker for renal function and associated with all-cause mortality after ischemic stroke. The aim of the current study was to characterise the environmental and genetic contributions to inter-individual variability of these biomarkers.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 19%
Researcher 7 13%
Student > Bachelor 6 12%
Student > Doctoral Student 5 10%
Other 5 10%
Other 14 27%
Unknown 5 10%
Readers by discipline Count As %
Medicine and Dentistry 16 31%
Biochemistry, Genetics and Molecular Biology 6 12%
Nursing and Health Professions 2 4%
Agricultural and Biological Sciences 2 4%
Veterinary Science and Veterinary Medicine 2 4%
Other 12 23%
Unknown 12 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 October 2015.
All research outputs
#15,739,529
of 25,374,647 outputs
Outputs from Circulation: Genomic and Precision Medicine
#756
of 1,062 outputs
Outputs of similar age
#137,188
of 262,315 outputs
Outputs of similar age from Circulation: Genomic and Precision Medicine
#13
of 24 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,062 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.0. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,315 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.