Title |
Genome-wide interaction of genotype by erythrocyte n-3 fatty acids contributes to phenotypic variance of diabetes-related traits
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Published in |
BMC Genomics, September 2014
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DOI | 10.1186/1471-2164-15-781 |
Pubmed ID | |
Authors |
Ju-Sheng Zheng, Chao-Qiang Lai, Laurence D Parnell, Yu-Chi Lee, Jian Shen, Caren E Smith, Patricia Casas-Agustench, Kris Richardson, Duo Li, Sabrina E Noel, Katherine L Tucker, Donna K Arnett, Ingrid B Borecki, José M Ordovás |
Abstract |
Little is known about the interplay between n-3 fatty acids and genetic variants for diabetes-related traits at the genome-wide level. The present study aimed to examine variance contributions of genotype by environment (GxE) interactions for different erythrocyte n-3 fatty acids and genetic variants for diabetes-related traits at the genome-wide level in a non-Hispanic white population living in the U.S.A. (n = 820). A tool for Genome-wide Complex Trait Analysis (GCTA) was used to estimate the genome-wide GxE variance contribution of four diabetes-related traits: HOMA-Insulin Resistance (HOMA-IR), fasting plasma insulin, glucose and adiponectin. A GxE genome-wide association study (GWAS) was conducted to further elucidate the GCTA results. Replication was conducted in the participants of the Boston Puerto Rican Health Study (BPRHS) without diabetes (n = 716). |
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