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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Enhancer alterations in cancer: a source for a cell identity crisis
|
|---|---|
| Published in |
Genome Medicine, September 2014
|
| DOI | 10.1186/s13073-014-0077-3 |
| Pubmed ID | |
| Authors |
Ken J Kron, Swneke D Bailey, Mathieu Lupien |
| Abstract |
Enhancers are selectively utilized to orchestrate gene expression programs that first govern pluripotency and then proceed to highly specialized programs required for the process of cellular differentiation. Whereas gene-proximal promoters are typically active across numerous cell types, distal enhancer activation is cell-type-specific and central to cell fate determination, thereby accounting for cell identity. Recent studies have highlighted the diversity of enhancer usage, cataloguing millions of such elements in the human genome. The disruption of enhancer activity, through genetic or epigenetic alterations, can impact cell-type-specific functions, resulting in a wide range of pathologies. In cancer, these alterations can promote a 'cell identity crisis', in which enhancers associated with oncogenes and multipotentiality are activated, while those promoting cell fate commitment are inactivated. Overall, these alterations favor an undifferentiated cellular phenotype. Here, we review the current knowledge regarding the role of enhancers in normal cell function, and discuss how genetic and epigenetic changes in enhancer elements potentiate oncogenesis. In addition, we discuss how understanding the mechanisms regulating enhancer activity can inform therapeutic opportunities in cancer cells and highlight key challenges that remain in understanding enhancer biology as it relates to oncology. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 33% |
| Belgium | 1 | 11% |
| United Kingdom | 1 | 11% |
| Germany | 1 | 11% |
| Canada | 1 | 11% |
| Unknown | 2 | 22% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 5 | 56% |
| Members of the public | 4 | 44% |
Mendeley readers
The data shown below were compiled from readership statistics for 140 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Denmark | 1 | <1% |
| China | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Luxembourg | 1 | <1% |
| Unknown | 133 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 33 | 24% |
| Student > Ph. D. Student | 29 | 21% |
| Student > Master | 23 | 16% |
| Student > Bachelor | 14 | 10% |
| Student > Doctoral Student | 9 | 6% |
| Other | 17 | 12% |
| Unknown | 15 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 58 | 41% |
| Biochemistry, Genetics and Molecular Biology | 51 | 36% |
| Medicine and Dentistry | 6 | 4% |
| Computer Science | 2 | 1% |
| Neuroscience | 2 | 1% |
| Other | 6 | 4% |
| Unknown | 15 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 May 2015.
All research outputs
#6,942,562
of 22,764,165 outputs
Outputs from Genome Medicine
#1,093
of 1,437 outputs
Outputs of similar age
#73,841
of 251,975 outputs
Outputs of similar age from Genome Medicine
#25
of 41 outputs
Altmetric has tracked 22,764,165 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 1,437 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.7. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,975 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.