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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Effects of early thyroxine treatment on development and growth at age 10.7 years: follow-up of a randomized placebo-controlled trial in children with Down's syndrome.
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|---|---|
| Published in |
JCEM, December 2014
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| DOI | 10.1210/jc.2014-2849 |
| Pubmed ID | |
| Authors |
Jan Pieter Marchal, Heleen Maurice-Stam, Nadine A Ikelaar, Femke C C Klouwer, Kim W J Verhorstert, M Emma Witteveen, Bregje A Houtzager, Martha A Grootenhuis, A S Paul van Trotsenburg |
| Abstract |
Context: In 2-years-old children with Down syndrome (DS), early T4 treatment was found to result in slightly better motor development and growth. Objectives: To determine long-term effects of early T4 treatment on development and growth in children with DS with either an elevated or normal neonatal TSH concentration. Design: Single follow-up visit, 8.7 years after a randomized placebo controlled trial (RCT) comparing T4 and placebo treatment during the first two years of life. Setting: Dutch Academic Hospital. Participants: All children who completed the RCT (N=181, of 196 randomized children) were invited for the follow-up study. 123 participants enrolled, at a mean age of 10.7 years. Interventions: T4 or placebo treatment from the neonatal period until age two years. Main outcome measures: Primary: mental and motor development. Secondary: communication skills, fine-motor coordination, height, weight, and head circumference (HC). Outcomes were compared between T4 and placebo-treated children, and between treatment groups with either normal (<5 mIU/L), or elevated (≥5 mIU/L) TSH concentration at original trial entry. Results: Mental or motor development, communication skills, or fine-motor coordination did not differ between T4 (N=64) and placebo treated-children (N=59). T4-treated children had a larger HC (50.4 vs. 49.8 cm, P=.04) and tended to be taller (133.2 vs. 131.1 cm, P=.06). These differences were somewhat greater in children with TSH ≥5 mIU/L (HC: T4 50.5 vs. placebo 49.7 cm, P=.01; height: T4 133.8 vs. placebo 130.8 cm, P=.02), but were not found in children with TSH <5 mIU/L (HC: T4 50.1 vs. placebo 50.0 cm, P=.75; height: T4 132.1 vs. placebo 131.6 cm, P=.22). Conclusions: Early T4 treatment of children with DS does not appear to benefit mental or motor development later in life. However, the positive effect on growth is still measurable, especially in children with an elevated plasma TSH concentration in the neonatal period. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 76 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 13% |
| Student > Master | 9 | 12% |
| Student > Bachelor | 7 | 9% |
| Student > Ph. D. Student | 6 | 8% |
| Student > Postgraduate | 5 | 7% |
| Other | 14 | 18% |
| Unknown | 25 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 31 | 41% |
| Sports and Recreations | 3 | 4% |
| Neuroscience | 3 | 4% |
| Social Sciences | 3 | 4% |
| Psychology | 2 | 3% |
| Other | 7 | 9% |
| Unknown | 27 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 March 2015.
All research outputs
#15,170,530
of 25,377,790 outputs
Outputs from JCEM
#11,454
of 15,434 outputs
Outputs of similar age
#192,652
of 369,139 outputs
Outputs of similar age from JCEM
#117
of 238 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 15,434 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.6. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 369,139 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 238 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.