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Receiver operating characteristic (ROC) curve for classification of18F-NaF uptake on PET/CT

Overview of attention for article published in Radiologia Brasileira, February 2016
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Title
Receiver operating characteristic (ROC) curve for classification of18F-NaF uptake on PET/CT
Published in
Radiologia Brasileira, February 2016
DOI 10.1590/0100-3984.2014.0119
Pubmed ID
Authors

Agnes Araujo Valadares, Paulo Schiavom Duarte, Giovanna Carvalho, Carla Rachel Ono, George Barberio Coura-Filho, Heitor Naoki Sado, Marcelo Tatit Sapienza, Carlos Alberto Buchpiguel

Abstract

To assess the cutoff values established by ROC curves to classify (18)F-NaF uptake as normal or malignant. PET/CT images were acquired 1 hour after administration of 185 MBq of (18)F-NaF. Volumes of interest (VOIs) were drawn on three regions of the skeleton as follows: proximal right humerus diaphysis (HD), proximal right femoral diaphysis (FD) and first vertebral body (VB1), in a total of 254 patients, totalling 762 VOIs. The uptake in the VOIs was classified as normal or malignant on the basis of the radiopharmaceutical distribution pattern and of the CT images. A total of 675 volumes were classified as normal and 52 were classified as malignant. Thirty-five VOIs classified as indeterminate or nonmalignant lesions were excluded from analysis. The standardized uptake value (SUV) measured on the VOIs were plotted on an ROC curve for each one of the three regions. The area under the ROC (AUC) as well as the best cutoff SUVs to classify the VOIs were calculated. The best cutoff values were established as the ones with higher result of the sum of sensitivity and specificity. The AUCs were 0.933, 0.889 and 0.975 for UD, FD and VB1, respectively. The best SUV cutoffs were 9.0 (sensitivity: 73%; specificity: 99%), 8.4 (sensitivity: 79%; specificity: 94%) and 21.0 (sensitivity: 93%; specificity: 95%) for UD, FD and VB1, respectively. The best cutoff value varies according to bone region of analysis and it is not possible to establish one value for the whole body.

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Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Other 3 33%
Student > Master 2 22%
Student > Ph. D. Student 1 11%
Student > Doctoral Student 1 11%
Student > Bachelor 1 11%
Other 0 0%
Unknown 1 11%
Readers by discipline Count As %
Medicine and Dentistry 3 33%
Computer Science 1 11%
Nursing and Health Professions 1 11%
Arts and Humanities 1 11%
Neuroscience 1 11%
Other 1 11%
Unknown 1 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 October 2017.
All research outputs
#10,546,972
of 11,902,314 outputs
Outputs from Radiologia Brasileira
#187
of 246 outputs
Outputs of similar age
#230,404
of 273,672 outputs
Outputs of similar age from Radiologia Brasileira
#3
of 3 outputs
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