Title |
Should we consider the infusion of lipid emulsion in the resuscitation of poisoned patients?
|
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Published in |
Critical Care, July 2014
|
DOI | 10.1186/s13054-014-0457-5 |
Pubmed ID | |
Authors |
Grant Cave, Martyn G Harvey |
Abstract |
The use of intravenous lipid emulsions (ILEs) as antidote in local anaesthetic systemic toxicity has gained widespread support following convincing data from animal models, and successful case reports in humans. Proposed beneficial mechanisms of action for ILEs include intravascular sequestration of intoxicant and subsequent enhanced redistribution to biologically inert tissues, augmentation of fatty acid utilisation for ATP synthesis in the context of metabolic poisoning, and direct cardiotonic and ion channel effects. The evidence base for use of ILEs in acute drug intoxication is evolving. The present evidence supports use of ILEs only in local anaesthetic systemic toxicity and in lipophilic cardiotoxin intoxication when there is an immediate threat to life, and other therapies have proven ineffective. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 25% |
Greece | 1 | 13% |
Spain | 1 | 13% |
South Africa | 1 | 13% |
Unknown | 3 | 38% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Science communicators (journalists, bloggers, editors) | 3 | 38% |
Practitioners (doctors, other healthcare professionals) | 3 | 38% |
Members of the public | 2 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | 3% |
Unknown | 39 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 20% |
Other | 7 | 18% |
Student > Bachelor | 4 | 10% |
Student > Ph. D. Student | 4 | 10% |
Student > Postgraduate | 4 | 10% |
Other | 8 | 20% |
Unknown | 5 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 25 | 63% |
Veterinary Science and Veterinary Medicine | 5 | 13% |
Agricultural and Biological Sciences | 2 | 5% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Immunology and Microbiology | 1 | 3% |
Other | 1 | 3% |
Unknown | 5 | 13% |