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International Consensus Statement on the Clinical and Therapeutic Management of Leber Hereditary Optic Neuropathy

Overview of attention for article published in Journal of Neuro-Ophthalmology, December 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#4 of 1,077)
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

news
7 news outlets
policy
1 policy source
twitter
4 tweeters

Citations

dimensions_citation
69 Dimensions

Readers on

mendeley
74 Mendeley
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Title
International Consensus Statement on the Clinical and Therapeutic Management of Leber Hereditary Optic Neuropathy
Published in
Journal of Neuro-Ophthalmology, December 2017
DOI 10.1097/wno.0000000000000570
Pubmed ID
Authors

Valerio Carelli, Michele Carbonelli, Irenaeus F. de Coo, Aki Kawasaki, Thomas Klopstock, Wolf A. Lagrèze, Chiara La Morgia, Nancy J. Newman, Christophe Orssaud, Jan Willem R. Pott, Alfredo A. Sadun, Judith van Everdingen, Catherine Vignal-Clermont, Marcela Votruba, Patrick Yu-Wai-Man, Piero Barboni

Abstract

Leber hereditary optic neuropathy (LHON) is currently estimated as the most frequent mitochondrial disease (1 in 27,000-45,000). Its molecular pathogenesis and natural history is now fairly well understood. LHON also is the first mitochondrial disease for which a treatment has been approved (idebenone-Raxone, Santhera Pharmaceuticals) by the European Medicine Agency, under exceptional circumstances because of the rarity and severity of the disease. However, what remains unclear includes the optimal target population, timing, dose, and frequency of administration of idebenone in LHON due to lack of accepted definitions, criteria, and general guidelines for the clinical management of LHON. To address these issues, a consensus conference with a panel of experts from Europe and North America was held in Milan, Italy, in 2016. The intent was to provide expert consensus statements for the clinical and therapeutic management of LHON based on the currently available evidence. We report the conclusions of this conference, providing the guidelines for clinical and therapeutic management of LHON.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 74 100%

Demographic breakdown

Readers by professional status Count As %
Other 13 18%
Researcher 10 14%
Student > Bachelor 9 12%
Student > Master 8 11%
Student > Ph. D. Student 6 8%
Other 14 19%
Unknown 14 19%
Readers by discipline Count As %
Medicine and Dentistry 30 41%
Biochemistry, Genetics and Molecular Biology 8 11%
Neuroscience 7 9%
Agricultural and Biological Sciences 5 7%
Pharmacology, Toxicology and Pharmaceutical Science 4 5%
Other 6 8%
Unknown 14 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 61. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2018.
All research outputs
#370,084
of 15,826,755 outputs
Outputs from Journal of Neuro-Ophthalmology
#4
of 1,077 outputs
Outputs of similar age
#11,946
of 281,268 outputs
Outputs of similar age from Journal of Neuro-Ophthalmology
#1
of 30 outputs
Altmetric has tracked 15,826,755 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,077 research outputs from this source. They receive a mean Attention Score of 2.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,268 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.