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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The prognostic significance of RUNX2 and miR-10a/10b and their inter-relationship in breast cancer
|
|---|---|
| Published in |
Journal of Translational Medicine, September 2014
|
| DOI | 10.1186/s12967-014-0257-3 |
| Pubmed ID | |
| Authors |
Chih-Hao Chang, Tan-Chi Fan, Jyh-Cherng Yu, Guo-Shiou Liao, You-Chin Lin, Arthur Chun-Chieh Shih, Wen-Hsiung Li, Alice Lin-Tsing Yu |
| Abstract |
BackgroundThe major cancer related mortality is caused by metastasis and invasion. It is important to identify genes regulating metastasis and invasion in order to curtail metastatic spread of cancer cells.MethodsThis study investigated the association between RUNX2 and miR-10a/miR-10b and the risk of breast cancer relapse. Expression levels of RUNX2 and miR-10a/b in108 pairs of tumor and non-tumor tissue of breast cancer were assayed by quantitative PCR analysis and evaluated for their prognostic implications.ResultsThe median expression levels of RUNX2 and miR-10b in tumor tissue normalized using adjacent non-tumor tissue were significantly higher in relapsed patients than in relapse-free patients. Higher expression of these three genes were significantly correlated with the hazard ratio for breast cancer recurrence (RUNX2: 3.02, 95% CI¿=¿1.50¿~¿6.07; miR-10a: 2.31, 95% CI¿=¿1.00¿~¿5.32; miR-10b: 3.96, 95% CI¿=¿1.21¿~¿12.98). The joint effect of higher expression of all three genes was associated with a hazard ratio of 12.37 (95% CI¿=¿1.62¿~¿94.55) for relapse. In a breast cancer cell line, RUNX2 silencing reduced the expression of miR-10a/b and also impaired cell motility, while RUNX2 overexpression elicited opposite effects.ConclusionsThese findings indicate that higher expression of RUNX2 and miR-10a/b was associated with adverse outcome of breast cancer. Expression levels of RUNX2 and miR-10a/b individually or jointly are potential prognostic factors for predicting breast cancer recurrence. Data from in vitro studies support the notion that RUNX2 promoted cell motility by upregulating miR-10a/b. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 29 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 21% |
| Researcher | 4 | 14% |
| Student > Bachelor | 3 | 10% |
| Student > Doctoral Student | 2 | 7% |
| Professor > Associate Professor | 2 | 7% |
| Other | 5 | 17% |
| Unknown | 7 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 34% |
| Medicine and Dentistry | 5 | 17% |
| Agricultural and Biological Sciences | 4 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
| Nursing and Health Professions | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 8 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 October 2014.
All research outputs
#18,379,655
of 22,765,347 outputs
Outputs from Journal of Translational Medicine
#2,941
of 3,980 outputs
Outputs of similar age
#180,445
of 252,706 outputs
Outputs of similar age from Journal of Translational Medicine
#51
of 81 outputs
Altmetric has tracked 22,765,347 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,980 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
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We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.