Title |
Recent advances in renal interstitial fibrosis and tubular atrophy after kidney transplantation
|
---|---|
Published in |
Fibrogenesis & Tissue Repair, October 2014
|
DOI | 10.1186/1755-1536-7-15 |
Pubmed ID | |
Authors |
Xiaojun Li, Shougang Zhuang |
Abstract |
Although kidney transplantation has been an important means for the treatment of patients with end stage of renal disease, the long-term survival rate of the renal allograft remains a challenge. The cause of late renal allograft loss, once known as chronic allograft nephropathy, has been renamed "interstitial fibrosis and tubular atrophy" (IF/TA) to reflect the histologic pattern seen on biopsy. The mechanisms leading to IF/TA in the transplanted kidney include inflammation, activation of renal fibroblasts, and deposition of extracellular matrix proteins. Identifying the mediators and factors that trigger IF/TA may be useful in early diagnosis and development of novel therapeutic strategies for improving long-term renal allograft survival and patient outcomes. In this review, we highlight the recent advances in our understanding of IF/TA from three aspects: pathogenesis, diagnosis, and treatment. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 54 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 18 | 33% |
Researcher | 8 | 15% |
Student > Bachelor | 6 | 11% |
Other | 4 | 7% |
Student > Doctoral Student | 3 | 6% |
Other | 6 | 11% |
Unknown | 9 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 18 | 33% |
Agricultural and Biological Sciences | 7 | 13% |
Biochemistry, Genetics and Molecular Biology | 5 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Engineering | 2 | 4% |
Other | 6 | 11% |
Unknown | 14 | 26% |