Title |
Aminated nanomicelles as a designer vaccine adjuvant to trigger inflammasomes and multiple arms of the innate immune response in lymph nodes
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Published in |
International Journal of Nanomedicine, October 2017
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DOI | 10.2147/ijn.s144623 |
Pubmed ID | |
Authors |
Chanyoung Song, Hathaichanok Phuengkham, Sun-Young Kim, Min Sang Lee, Ji Hoon Jeong, Sung Jae Shin, Yong Taik Lim |
Abstract |
In this study, we suggest a designer vaccine adjuvant that can mimic the drainage of pathogens into lymph nodes and activate innate immune response in lymph nodes. By the amination of multivalent carboxyl groups in poly-(γ-glutamic acid) (γ-PGA) nanomicelles, the size was reduced for rapid entry into lymphatic vessels, and the immunologically inert nanomicelles were turned into potential activators of inflammasomes. Aminated γ-PGA nanomicelles (aPNMs) induced NLRP3 inflammasome activation and the subsequent release of proinflammatory IL-1β. The NLRP3-dependent inflammasome induction mechanism was confirmed through enzyme (cathepsin B and caspase-1) inhibitors and NLRP3 knockout mice model. After the aPNMs were combined with a clinically evaluated TLR3 agonist, polyinosinic-polycytidylic acid sodium salt (aPNM-IC), they triggered multiple arms of the innate immune response, including the secretion of pro-inflammatory cytokines by both inflammasomes and an inflammasome-independent pathway and the included type I interferons. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 16 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 31% |
Student > Postgraduate | 2 | 13% |
Lecturer > Senior Lecturer | 1 | 6% |
Student > Bachelor | 1 | 6% |
Other | 1 | 6% |
Other | 2 | 13% |
Unknown | 4 | 25% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 4 | 25% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 13% |
Agricultural and Biological Sciences | 2 | 13% |
Neuroscience | 1 | 6% |
Unknown | 7 | 44% |