Title |
Role of MicroRNA Modulation in the Interferon-α/Ribavirin Suppression of HIV-1 In Vivo
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Published in |
PLOS ONE, October 2014
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DOI | 10.1371/journal.pone.0109220 |
Pubmed ID | |
Authors |
Mohamed Abdel-Mohsen, Xutao Deng, Ali Danesh, Teri Liegler, Evan S. Jacobs, Andri Rauch, Bruno Ledergerber, Philip J. Norris, Huldrych F. Günthard, Joseph K. Wong, Satish K. Pillai |
Abstract |
Interferon-α (IFN-α) treatment suppresses HIV-1 viremia and reduces the size of the HIV-1 latent reservoir. Therefore, investigation of the molecular and immunologic effects of IFN-α may provide insights that contribute to the development of novel prophylactic, therapeutic and curative strategies for HIV-1 infection. In this study, we hypothesized that microRNAs (miRNAs) contribute to the IFN-α-mediated suppression of HIV-1. To inform the development of novel miRNA-based antiretroviral strategies, we investigated the effects of exogenous IFN-α treatment on global miRNA expression profile, HIV-1 viremia, and potential regulatory networks between miRNAs and cell-intrinsic anti-HIV-1 host factors in vivo. |
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Mendeley readers
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