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Exploring the Human-Nipah Virus Protein-Protein Interactome

Overview of attention for article published in Journal of Virology, November 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

twitter
25 tweeters

Citations

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23 Dimensions

Readers on

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58 Mendeley
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Title
Exploring the Human-Nipah Virus Protein-Protein Interactome
Published in
Journal of Virology, November 2017
DOI 10.1128/jvi.01461-17
Pubmed ID
Authors

Luis Martinez-Gil, Natalia M. Vera-Velasco, Ismael Mingarro

Abstract

Nipah virus is an emerging, highly pathogenic, zoonotic virus of the paramyxoviridiae family. Human transmission occurs by close contact with infected animals, the consumption of contaminated food, or, occasionally, via other infected individuals. Currently, we lack therapeutic or prophylactic treatments for Nipah virus. To develop these agents we must now improve our understanding of the host-virus interactions that underpin a productive infection. This aim led us to perform the present work, in which we identified (101) human-Nipah virus protein-protein interactions (PPIs), most of which (88) are novel. This dataset provides a comprehensive view of the host complexes that are manipulated by viral proteins. Host targets include the PRP19 complex and the miRNA processing machinery. Furthermore, we explored the biologic consequences of the interaction with the PRP19 complex and found that the Nipah virus W protein is capable of altering p53 control and gene expression. We anticipate that these data will help in guiding the development of novel interventional strategies to counter this emerging viral threat.IMPORTANCE Nipah virus is recently discovered virus that infects a wide range of mammals, including humans. Since its discovery there have been yearly outbreaks and in some of them the mortality rate has reach 100% of the confirmed cases. However, the study of Nipah virus has been largely neglected and currently we lack treatments for this infection. To develop these agents we must now improve our understanding of the host-virus interactions that underpin a productive infection. In the present work we identified 101 human-Nipah virus protein-protein interactions using an affinity purification approach coupled with mass spectrometry. Additionally, we explored the cellular consequences of some of these interactions. Globally, this dataset offers a comprehensive and detailed view of the host machinery's contribution to the Nipah virus's life cycle. Furthermore, our data present a large number of putative drug targets that could be exploited for the treatment of this infection.

Twitter Demographics

The data shown below were collected from the profiles of 25 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 58 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 17%
Student > Master 9 16%
Researcher 9 16%
Student > Ph. D. Student 9 16%
Professor 4 7%
Other 9 16%
Unknown 8 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 17 29%
Agricultural and Biological Sciences 11 19%
Immunology and Microbiology 6 10%
Chemistry 4 7%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Other 5 9%
Unknown 12 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 May 2018.
All research outputs
#1,280,149
of 14,571,155 outputs
Outputs from Journal of Virology
#676
of 13,989 outputs
Outputs of similar age
#37,928
of 278,140 outputs
Outputs of similar age from Journal of Virology
#25
of 272 outputs
Altmetric has tracked 14,571,155 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,989 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,140 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 272 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.