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Thalamic metabolic abnormalities in patients with Huntington's disease measured by magnetic resonance spectroscopy.

Overview of attention for article published in Brazilian Journal of Medical and Biological Research, August 2013
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1 tweeter

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Title
Thalamic metabolic abnormalities in patients with Huntington's disease measured by magnetic resonance spectroscopy.
Published in
Brazilian Journal of Medical and Biological Research, August 2013
DOI 10.1590/1414-431x20132332
Pubmed ID
Authors

Casseb RF, D'Abreu A, Ruocco HH, Lopes-Cendes I, Cendes F, Castellano G

Abstract

Huntington's disease (HD) is a neurologic disorder that is not completely understood; its fundamental physiological mechanisms and chemical effects remain somewhat unclear. Among these uncertainties, we can highlight information about the concentrations of brain metabolites, which have been widely discussed. Concentration differences in affected, compared to healthy, individuals could lead to the development of useful tools for evaluating the progression of disease, or to the advance of investigations of different/alternative treatments. The aim of this study was to compare the thalamic concentration of metabolites in HD patients and healthy individuals using magnetic resonance spectroscopy. We used a 2.0-Tesla magnetic field, repetition time of 1500 ms, and echo time of 135 ms. Spectra from 40 adult HD patients and 26 control subjects were compared. Quantitative analysis was performed using the LCModel method. There were statistically significant differences between HD patients and controls in the concentrations of N-acetylaspartate+N-acetylaspartylglutamate (NAA+NAAG; t-test, P<0.001), and glycerophosphocholine+phosphocholine (GPC+PCh; t-test, P=0.001) relative to creatine+phosphocreatine (Cr+PCr). The NAA+NAAG/Cr+PCr ratio was decreased by 9% and GPC+PCh/Cr+PCr increased by 17% in patients compared with controls. There were no correlations between the concentration ratios and clinical features. Although these results could be caused by T1 and T2 changes, rather than variations in metabolite concentrations given the short repetition time and long echo time values used, our findings point to thalamic dysfunction, corroborating prior evidence.

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Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Egypt 1 3%
Unknown 32 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 24%
Student > Bachelor 4 12%
Researcher 4 12%
Other 3 9%
Student > Master 3 9%
Other 5 15%
Unknown 7 21%
Readers by discipline Count As %
Medicine and Dentistry 11 32%
Neuroscience 4 12%
Agricultural and Biological Sciences 2 6%
Biochemistry, Genetics and Molecular Biology 1 3%
Psychology 1 3%
Other 3 9%
Unknown 12 35%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 October 2014.
All research outputs
#2,325,968
of 4,506,116 outputs
Outputs from Brazilian Journal of Medical and Biological Research
#141
of 361 outputs
Outputs of similar age
#58,048
of 119,929 outputs
Outputs of similar age from Brazilian Journal of Medical and Biological Research
#3
of 21 outputs
Altmetric has tracked 4,506,116 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 361 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 119,929 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.