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Efficacy and safety for Apatinib treatment in advanced gastric cancer: a real world study

Overview of attention for article published in Scientific Reports, October 2017
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Title
Efficacy and safety for Apatinib treatment in advanced gastric cancer: a real world study
Published in
Scientific Reports, October 2017
DOI 10.1038/s41598-017-13192-8
Pubmed ID
Authors

Yong Zhang, Chun Han, Juan Li, Li Zhang, Lijie Wang, Sisi Ye, Yi Hu, Li Bai

Abstract

Apatinib has been proved to be effective and safe among patients in gastric cancer in Phase II and III Trials. We aimed to evaluate its efficacy and safety in real world practice, and to explore factors associated with efficacy. Between January 2015 and February 2017, totally 36 patients with advanced gastric adenocarcinoma or adenocarcinoma of gastroesophageal junction (GEJ) were enrolled and followed up retrospectively after failing at least two lines of systemic therapy. The mPFS was 2.65 months (95%CI 1.66-3.54), and mOS was 5.8 months (95%CI 4.77-6.83). Two patients achieved partial response, and nineteen achieved stable disease. The disease control rate (DCR) was 58.3%, and objective response rate (ORR) was 5.6%. Common grade adverse events were hypertension (38.9%), proteinuria (36.1%), and neutropenia (33.3%). And the most common adverse events over grade 3 were hand-foot syndrome (8.3%), anemia (5.6%), and diarrhea (5.6%). No treatment-related death was documented during the drug administration. Exploratory analyses indicated patients treated with antiangiogenic therapy previously were more likely to benefit from apatinib.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 38%
Student > Master 2 25%
Student > Postgraduate 1 13%
Professor 1 13%
Student > Doctoral Student 1 13%
Other 0 0%
Readers by discipline Count As %
Medicine and Dentistry 2 25%
Agricultural and Biological Sciences 1 13%
Unspecified 1 13%
Arts and Humanities 1 13%
Immunology and Microbiology 1 13%
Other 2 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2017.
All research outputs
#10,635,756
of 11,991,714 outputs
Outputs from Scientific Reports
#43,517
of 53,003 outputs
Outputs of similar age
#231,794
of 275,399 outputs
Outputs of similar age from Scientific Reports
#2,696
of 3,413 outputs
Altmetric has tracked 11,991,714 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
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