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Activation of Olfactory Receptors on Mouse Pulmonary Macrophages Promotes Monocyte Chemotactic Protein-1 Production

Overview of attention for article published in PLOS ONE, November 2013
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Title
Activation of Olfactory Receptors on Mouse Pulmonary Macrophages Promotes Monocyte Chemotactic Protein-1 Production
Published in
PLOS ONE, November 2013
DOI 10.1371/journal.pone.0080148
Pubmed ID
Authors

Jing Jing Li, Hock L. Tay, Maximilian Plank, Ama-Tawiah Essilfie, Philip M. Hansbro, Paul S. Foster, Ming Yang

Abstract

Emerging evidence suggests that non-olfactory tissues and cells can express olfactory receptors (ORs), however, the exact function of ectopic OR expression remains unknown. We have previously shown in mouse models that a unique cooperation between interferon-γ (IFN-γ) and lipopolysaccharide (LPS) drives the activation of pulmonary macrophages and leads to the induction of pathogenic responses in the respiratory tract. Further, through gene array studies, we have shown that activation of macrophages by these molecules results in the selective expression of a number of ORs. In this study, we validated the expression of these ORs in mouse airway and pulmonary macrophages in response to IFN-γ and LPS (γ/LPS) stimulation, and further explored the effect of odorant stimulation on macrophage function.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 1%
United States 1 1%
Unknown 67 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 22%
Student > Ph. D. Student 11 16%
Student > Master 8 12%
Student > Bachelor 6 9%
Professor 4 6%
Other 11 16%
Unknown 14 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 17 25%
Agricultural and Biological Sciences 13 19%
Immunology and Microbiology 7 10%
Medicine and Dentistry 5 7%
Neuroscience 3 4%
Other 6 9%
Unknown 18 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 October 2014.
All research outputs
#18,379,655
of 22,765,347 outputs
Outputs from PLOS ONE
#154,423
of 194,205 outputs
Outputs of similar age
#227,864
of 302,086 outputs
Outputs of similar age from PLOS ONE
#3,889
of 5,173 outputs
Altmetric has tracked 22,765,347 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 194,205 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 302,086 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5,173 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.