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Downregulation of inhibitory SRC Homology 2 Domain-containing Phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly.

Overview of attention for article published in Cell Communication and Signaling, January 2014
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1 tweeter

Citations

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17 Mendeley
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Title
Downregulation of inhibitory SRC Homology 2 Domain-containing Phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly.
Published in
Cell Communication and Signaling, January 2014
DOI 10.1186/1478-811x-12-2
Pubmed ID
Authors

Lepage A, Fortin C, Garneau H, Allard N, Tsvetkova K, Ying CT, Larbi A, Dupuis G, Fülöp T

Abstract

Immune responses are generally impaired in aged mammals. T cells have been extensively studied in this context due to the initial discovery of their reduced proliferative capacity with aging. The decreased responses involve altered signaling events associated with the early steps of T cell activation. The underlying causes of these changes are not fully understood but point to alterations in assembly of the machinery for T cell activation. Here, we have tested the hypothesis that the T cell pool in elderly subjects displayed reduced functional capacities due to altered negative feedback mechanisms that participate in the regulation of the early steps of T cell activation. Such conditions tip the immune balance in favor of altered T cell activation and a related decreased response in aging.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 6%
Unknown 16 94%

Demographic breakdown

Readers by professional status Count As %
Unspecified 5 29%
Student > Ph. D. Student 5 29%
Student > Master 2 12%
Student > Bachelor 2 12%
Other 1 6%
Other 2 12%
Readers by discipline Count As %
Unspecified 7 41%
Agricultural and Biological Sciences 4 24%
Nursing and Health Professions 1 6%
Business, Management and Accounting 1 6%
Computer Science 1 6%
Other 3 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 October 2014.
All research outputs
#3,406,824
of 4,340,057 outputs
Outputs from Cell Communication and Signaling
#81
of 120 outputs
Outputs of similar age
#90,360
of 116,943 outputs
Outputs of similar age from Cell Communication and Signaling
#7
of 11 outputs
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So far Altmetric has tracked 120 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 4th percentile – i.e., 4% of its peers scored the same or lower than it.
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We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.