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Generation of Functional Human Pancreatic β Cells In Vitro

Overview of attention for article published in Cell, October 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Citations

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1125 Dimensions

Readers on

mendeley
1789 Mendeley
citeulike
6 CiteULike
Title
Generation of Functional Human Pancreatic β Cells In Vitro
Published in
Cell, October 2014
DOI 10.1016/j.cell.2014.09.040
Pubmed ID
Authors

Felicia W. Pagliuca, Jeffrey R. Millman, Mads Gürtler, Michael Segel, Alana Van Dervort, Jennifer Hyoje Ryu, Quinn P. Peterson, Dale Greiner, Douglas A. Melton

Abstract

The generation of insulin-producing pancreatic β cells from stem cells in vitro would provide an unprecedented cell source for drug discovery and cell transplantation therapy in diabetes. However, insulin-producing cells previously generated from human pluripotent stem cells (hPSC) lack many functional characteristics of bona fide β cells. Here, we report a scalable differentiation protocol that can generate hundreds of millions of glucose-responsive β cells from hPSC in vitro. These stem-cell-derived β cells (SC-β) express markers found in mature β cells, flux Ca(2+) in response to glucose, package insulin into secretory granules, and secrete quantities of insulin comparable to adult β cells in response to multiple sequential glucose challenges in vitro. Furthermore, these cells secrete human insulin into the serum of mice shortly after transplantation in a glucose-regulated manner, and transplantation of these cells ameliorates hyperglycemia in diabetic mice.

Twitter Demographics

The data shown below were collected from the profiles of 457 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 1,789 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 18 1%
United Kingdom 17 <1%
Japan 5 <1%
Belgium 3 <1%
Netherlands 3 <1%
Germany 3 <1%
Portugal 2 <1%
Italy 2 <1%
Spain 2 <1%
Other 18 1%
Unknown 1716 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 398 22%
Student > Bachelor 342 19%
Researcher 310 17%
Student > Master 224 13%
Student > Doctoral Student 93 5%
Other 272 15%
Unknown 150 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 571 32%
Biochemistry, Genetics and Molecular Biology 464 26%
Medicine and Dentistry 210 12%
Engineering 133 7%
Chemistry 35 2%
Other 185 10%
Unknown 191 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 900. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 December 2020.
All research outputs
#9,862
of 17,651,001 outputs
Outputs from Cell
#83
of 15,642 outputs
Outputs of similar age
#77
of 218,961 outputs
Outputs of similar age from Cell
#2
of 144 outputs
Altmetric has tracked 17,651,001 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15,642 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.2. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 218,961 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 144 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.