Title |
Chronic psychological stress and its impact on the development of aggressive breast cancer
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Published in |
Einstein (São Paulo), January 2015
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DOI | 10.1590/s1679-45082015ao3344 |
Pubmed ID | |
Authors |
Thayse Fachin Cormanique, Lirane Elize Defante Ferreto de Almeida, Cynthia Alba Rech, Daniel Rech, Ana Cristina da Silva do Amaral Herrera, Carolina Panis |
Abstract |
Objective To investigate the clinicopathological findings of women diagnosed with breast cancer and study the impact of chronic psychological stress on the pathological characteristics of these tumors.Methods We investigated a cohort composed of women diagnosed with breast cancer and divided into two groups. One group was categorized as presenting with chronic psychological stress (by using the Self-Reporting Questionnaire - SRQ-20). Another group of women with breast cancer, but with no previous history of chronic psychological stress, comprised the Control Group. Clinical and pathological data were assessed.Results Women presenting with a history of chronic distress were significantly overweight when compared to the Control Group. Furthermore, it was observed that these stressed women also had a significant percentage of aggressive breast cancer subtype, the HER2 amplified tumor, which could be putatively associated with the loss of immunosurveillance.Conclusion Our findings suggested an interaction among chronic psychological stress, overweight, and the development of more aggressive breast tumors. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 74 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 18 | 24% |
Student > Master | 8 | 11% |
Student > Doctoral Student | 7 | 9% |
Researcher | 6 | 8% |
Student > Ph. D. Student | 6 | 8% |
Other | 13 | 18% |
Unknown | 16 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 26 | 35% |
Psychology | 10 | 14% |
Nursing and Health Professions | 5 | 7% |
Biochemistry, Genetics and Molecular Biology | 4 | 5% |
Agricultural and Biological Sciences | 3 | 4% |
Other | 8 | 11% |
Unknown | 18 | 24% |