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Apigenin in cancer therapy: anti-cancer effects and mechanisms of action

Overview of attention for article published in Cell & Bioscience, October 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#15 of 1,156)
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (81st percentile)

Mentioned by

news
4 news outlets
twitter
8 X users
facebook
2 Facebook pages
wikipedia
1 Wikipedia page
video
1 YouTube creator

Citations

dimensions_citation
362 Dimensions

Readers on

mendeley
413 Mendeley
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Title
Apigenin in cancer therapy: anti-cancer effects and mechanisms of action
Published in
Cell & Bioscience, October 2017
DOI 10.1186/s13578-017-0179-x
Pubmed ID
Authors

Xiaohui Yan, Miao Qi, Pengfei Li, Yihong Zhan, Huanjie Shao

Abstract

Apigenin is a common dietary flavonoid that is abundantly present in many fruits, vegetables and Chinese medicinal herbs and serves multiple physiological functions, such as strong anti-inflammatory, antioxidant, antibacterial and antiviral activities and blood pressure reduction. Therefore, apigenin has been used as a traditional medicine for centuries. Recently, apigenin has been widely investigated for its anti-cancer activities and low toxicity. Apigenin was reported to suppress various human cancers in vitro and in vivo by multiple biological effects, such as triggering cell apoptosis and autophagy, inducing cell cycle arrest, suppressing cell migration and invasion, and stimulating an immune response. In this review, we focus on the most recent advances in the anti-cancer effects of apigenin and their underlying mechanisms, and we summarize the signaling pathways modulated by apigenin, including the PI3K/AKT, MAPK/ERK, JAK/STAT, NF-κB and Wnt/β-catenin pathways. We also discuss combinatorial strategies to enhance the anti-cancer effect of apigenin on various cancers and its use as an adjuvant chemotherapeutic agent to overcome cancer drug resistance or to alleviate other adverse effects of chemotherapy. The functions of apigenin against cancer stem cells are also summarized and discussed. These data demonstrate that apigenin is a promising reagent for cancer therapy. Apigenin appears to have the potential to be developed either as a dietary supplement or as an adjuvant chemotherapeutic agent for cancer therapy.

X Demographics

X Demographics

The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 413 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 413 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 46 11%
Student > Bachelor 46 11%
Student > Ph. D. Student 37 9%
Researcher 32 8%
Student > Doctoral Student 21 5%
Other 53 13%
Unknown 178 43%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 52 13%
Pharmacology, Toxicology and Pharmaceutical Science 46 11%
Agricultural and Biological Sciences 34 8%
Medicine and Dentistry 23 6%
Chemistry 22 5%
Other 37 9%
Unknown 199 48%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 43. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2024.
All research outputs
#947,429
of 25,126,845 outputs
Outputs from Cell & Bioscience
#15
of 1,156 outputs
Outputs of similar age
#19,661
of 328,676 outputs
Outputs of similar age from Cell & Bioscience
#3
of 11 outputs
Altmetric has tracked 25,126,845 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,156 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,676 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.