Title |
Genetic polymorphisms and asthma: findings from a case–control study in the Madeira island population
|
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Published in |
Biological Research, September 2014
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DOI | 10.1186/0717-6287-47-40 |
Pubmed ID | |
Authors |
Anabela Gonçalves Berenguer, Ana Teresa Fernandes, Susana Oliveira, Mariana Rodrigues, Pedro Ornelas, Diogo Romeira, Tânia Serrão, Alexandra Rosa, Rita Câmara |
Abstract |
Asthma is a complex disease influenced by multiple genetic and environmental factors. While Madeira has the highest prevalence of asthma in Portugal (14.6%), the effect of both genetic and environmental factors in this population has never been assessed. We categorized 98 asthma patients according to the Global Initiative for Asthma (GINA) guidelines, established their sensitization profile, and measured their forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) indexes. Selected single nucleotide polymorphisms (SNPs) were analysed as potential markers for asthma susceptibility and severity in the interleukin 4 (IL4), interleukin 13 (IL13), beta-2-adrenergic receptor (ADRB2), a disintegrin and metalloprotease 33 (ADAM33), gasdermin-like (GSDML) and the signal transducer and activator of transcription 6 (STAT6) genes comparatively to a population reference set. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 45 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 11% |
Student > Master | 4 | 9% |
Other | 3 | 7% |
Student > Postgraduate | 3 | 7% |
Student > Doctoral Student | 2 | 4% |
Other | 8 | 18% |
Unknown | 20 | 44% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 16% |
Biochemistry, Genetics and Molecular Biology | 4 | 9% |
Agricultural and Biological Sciences | 4 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Environmental Science | 1 | 2% |
Other | 3 | 7% |
Unknown | 24 | 53% |