Title |
Increase of IFN-γ and TNF-γ production in CD107a + NK-92 cells co-cultured with cervical cancer cell lines pre-treated with the HO-1 inhibitor
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Published in |
Cancer Cell International, October 2014
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DOI | 10.1186/s12935-014-0100-1 |
Pubmed ID | |
Authors |
Paulina Gómez-Lomelí, Alejandro Bravo-Cuellar, Georgina Hernández-Flores, Luis Felipe Jave-Suárez, Adriana Aguilar-Lemarroy, José Manuel Lerma-Díaz, Jorge Ramiro Domínguez-Rodríguez, Karina Sánchez-Reyes, Pablo Cesar Ortiz-Lazareno |
Abstract |
Natural killer (NK) cells eliminate virus-infected and tumor cells through the release of perforins and granzymes; they also produce Interferon gamma (IFN-γ) and Tumor necrosis factor alpha (TNF-α), which induce apoptosis in target cells. Many tumors express Heme oxygenase 1 (HO-1), and this expression has been associated with avoiding immunosuppression and apoptosis. In this work, HO-1+ Cervical cancer cell (CCC) lines were pre-treated with HO-1 inhibitor and we assessed whether this inhibition enhanced the sensitivity of CCC to NK cell activity. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 54 | 100% |
Demographic breakdown
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Researcher | 13 | 24% |
Student > Ph. D. Student | 10 | 19% |
Student > Doctoral Student | 6 | 11% |
Student > Master | 5 | 9% |
Student > Bachelor | 4 | 7% |
Other | 6 | 11% |
Unknown | 10 | 19% |
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Pharmacology, Toxicology and Pharmaceutical Science | 4 | 7% |
Other | 4 | 7% |
Unknown | 11 | 20% |