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Increase of IFN-γ and TNF-γ production in CD107a + NK-92 cells co-cultured with cervical cancer cell lines pre-treated with the HO-1 inhibitor

Overview of attention for article published in Cancer Cell International, October 2014
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Title
Increase of IFN-γ and TNF-γ production in CD107a + NK-92 cells co-cultured with cervical cancer cell lines pre-treated with the HO-1 inhibitor
Published in
Cancer Cell International, October 2014
DOI 10.1186/s12935-014-0100-1
Pubmed ID
Authors

Paulina Gómez-Lomelí, Alejandro Bravo-Cuellar, Georgina Hernández-Flores, Luis Felipe Jave-Suárez, Adriana Aguilar-Lemarroy, José Manuel Lerma-Díaz, Jorge Ramiro Domínguez-Rodríguez, Karina Sánchez-Reyes, Pablo Cesar Ortiz-Lazareno

Abstract

Natural killer (NK) cells eliminate virus-infected and tumor cells through the release of perforins and granzymes; they also produce Interferon gamma (IFN-γ) and Tumor necrosis factor alpha (TNF-α), which induce apoptosis in target cells. Many tumors express Heme oxygenase 1 (HO-1), and this expression has been associated with avoiding immunosuppression and apoptosis. In this work, HO-1+ Cervical cancer cell (CCC) lines were pre-treated with HO-1 inhibitor and we assessed whether this inhibition enhanced the sensitivity of CCC to NK cell activity.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 54 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 24%
Student > Ph. D. Student 10 19%
Student > Doctoral Student 6 11%
Student > Master 5 9%
Student > Bachelor 4 7%
Other 6 11%
Unknown 10 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 19%
Biochemistry, Genetics and Molecular Biology 10 19%
Medicine and Dentistry 8 15%
Immunology and Microbiology 7 13%
Pharmacology, Toxicology and Pharmaceutical Science 4 7%
Other 4 7%
Unknown 11 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2014.
All research outputs
#15,307,723
of 22,766,595 outputs
Outputs from Cancer Cell International
#820
of 1,793 outputs
Outputs of similar age
#147,220
of 253,596 outputs
Outputs of similar age from Cancer Cell International
#8
of 16 outputs
Altmetric has tracked 22,766,595 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,793 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 253,596 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.