Title |
Phosphorylation and arginine methylation mark histone H2A prior to deposition during Xenopus laevis development
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Published in |
Epigenetics & Chromatin, September 2014
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DOI | 10.1186/1756-8935-7-22 |
Pubmed ID | |
Authors |
Wei-Lin Wang, Lissa C Anderson, Joshua J Nicklay, Hongshan Chen, Matthew J Gamble, Jeffrey Shabanowitz, Donald F Hunt, David Shechter |
Abstract |
Stored, soluble histones in eggs are essential for early development, in particular during the maternally controlled early cell cycles in the absence of transcription. Histone post-translational modifications (PTMs) direct and regulate chromatin-templated transactions, so understanding the nature and function of pre-deposition maternal histones is essential to deciphering mechanisms of regulation of development, chromatin assembly, and transcription. Little is known about histone H2A pre-deposition modifications nor known about the transitions that occur upon the onset of zygotic control of the cell cycle and transcription at the mid-blastula transition (MBT). |
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