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Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma

Overview of attention for article published in Acta Neuropathologica, August 2014
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  • Above-average Attention Score compared to outputs of the same age (54th percentile)
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2 tweeters
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2 Facebook pages

Citations

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177 Dimensions

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128 Mendeley
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Title
Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma
Published in
Acta Neuropathologica, August 2014
DOI 10.1007/s00401-014-1326-7
Pubmed ID
Authors

Felix Sahm, David Reuss, Christian Koelsche, David Capper, Jens Schittenhelm, Stephanie Heim, David T. W. Jones, Stefan M. Pfister, Christel Herold-Mende, Wolfgang Wick, Wolf Mueller, Christian Hartmann, Werner Paulus, Andreas von Deimling

Abstract

Astrocytoma and oligodendroglioma are histologically and genetically well-defined entities. The majority of astrocytomas harbor concurrent TP53 and ATRX mutations, while most oligodendrogliomas carry the 1p/19q co-deletion. Both entities share high frequencies of IDH mutations. In contrast, oligoastrocytomas (OA) appear less clearly defined and, therefore, there is an ongoing debate whether these tumors indeed constitute an entity or whether they represent a mixed bag containing both astrocytomas and oligodendrogliomas. We investigated 43 OA diagnosed in different institutions employing histology, immunohistochemistry and in situ hybridization addressing surrogates for the molecular genetic markers IDH1R132H, TP53, ATRX and 1p/19q loss. In all but one OA the combination of nuclear p53 accumulation and ATRX loss was mutually exclusive with 1p/19q co-deletion. In 31/43 OA, only alterations typical for oligodendroglioma were observed, while in 11/43 OA, only indicators for mutations typical for astrocytomas were detected. A single case exhibited a distinct pattern, nuclear expression of p53, ATRX loss, IDH1 mutation and partial 1p/19q loss. However, this was the only patient undergoing radiotherapy prior to surgery, possibly contributing to the acquisition of this uncommon combination. In OA with oligodendroglioma typical alterations, the portions corresponding to astrocytic part were determined as reactive, while in OA with astrocytoma typical alterations the portions corresponding to oligodendroglial differentiation were neoplastic. These data provide strong evidence against the existence of an independent OA entity.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 128 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 2 2%
United States 1 <1%
Sweden 1 <1%
India 1 <1%
Unknown 123 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 17%
Student > Doctoral Student 18 14%
Researcher 17 13%
Student > Postgraduate 14 11%
Other 12 9%
Other 29 23%
Unknown 16 13%
Readers by discipline Count As %
Medicine and Dentistry 66 52%
Agricultural and Biological Sciences 18 14%
Neuroscience 13 10%
Biochemistry, Genetics and Molecular Biology 5 4%
Immunology and Microbiology 1 <1%
Other 5 4%
Unknown 20 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 November 2014.
All research outputs
#7,056,879
of 12,276,356 outputs
Outputs from Acta Neuropathologica
#1,256
of 1,539 outputs
Outputs of similar age
#95,965
of 223,473 outputs
Outputs of similar age from Acta Neuropathologica
#19
of 32 outputs
Altmetric has tracked 12,276,356 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,539 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 223,473 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.