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Vancomycin-bearing Synthetic Bone Graft Delivers rhBMP-2 and Promotes Healing of Critical Rat Femoral Segmental Defects

Overview of attention for article published in Clinical Orthopaedics & Related Research, August 2014
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Title
Vancomycin-bearing Synthetic Bone Graft Delivers rhBMP-2 and Promotes Healing of Critical Rat Femoral Segmental Defects
Published in
Clinical Orthopaedics & Related Research, August 2014
DOI 10.1007/s11999-014-3841-1
Pubmed ID
Authors

Jordan D. Skelly, Jeffrey Lange, Tera M. Filion, Xinning Li, David C. Ayers, Jie Song

Abstract

Bone grafts simultaneously delivering therapeutic proteins and antibiotics may be valuable in orthopaedic trauma care. Previously, we developed a poly(2-hydroxyethyl methacrylate)-nanocrystalline hydroxyapatite (pHEMA-nHA) synthetic bone graft that, when preabsorbed with 400-ng rhBMP-2/7, facilitated the functional repair of critical-size rat femoral defects. Recently, we showed that pHEMA-nHA effectively retains/releases vancomycin and rhBMP-2 in vitro. The success of such a strategy requires that the incorporation of vancomycin does not compromise the structural integrity of the graft nor its ability to promote bone healing.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 50 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 18%
Student > Master 8 16%
Researcher 7 14%
Student > Bachelor 4 8%
Professor 3 6%
Other 10 20%
Unknown 10 20%
Readers by discipline Count As %
Medicine and Dentistry 16 31%
Engineering 5 10%
Agricultural and Biological Sciences 4 8%
Materials Science 3 6%
Psychology 2 4%
Other 7 14%
Unknown 14 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2015.
All research outputs
#17,296,085
of 26,184,649 outputs
Outputs from Clinical Orthopaedics & Related Research
#5,437
of 7,430 outputs
Outputs of similar age
#140,022
of 243,322 outputs
Outputs of similar age from Clinical Orthopaedics & Related Research
#103
of 149 outputs
Altmetric has tracked 26,184,649 research outputs across all sources so far. This one is in the 31st percentile – i.e., 31% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,430 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,322 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 149 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.