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Vancomycin-bearing Synthetic Bone Graft Delivers rhBMP-2 and Promotes Healing of Critical Rat Femoral Segmental Defects

Overview of attention for article published in Clinical Orthopaedics & Related Research, August 2014
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (52nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

Mentioned by

twitter
3 tweeters
facebook
1 Facebook page

Citations

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12 Dimensions

Readers on

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42 Mendeley
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Title
Vancomycin-bearing Synthetic Bone Graft Delivers rhBMP-2 and Promotes Healing of Critical Rat Femoral Segmental Defects
Published in
Clinical Orthopaedics & Related Research, August 2014
DOI 10.1007/s11999-014-3841-1
Pubmed ID
Authors

Jordan D. Skelly, Jeffrey Lange, Tera M. Filion, Xinning Li, David C. Ayers, Jie Song

Abstract

Bone grafts simultaneously delivering therapeutic proteins and antibiotics may be valuable in orthopaedic trauma care. Previously, we developed a poly(2-hydroxyethyl methacrylate)-nanocrystalline hydroxyapatite (pHEMA-nHA) synthetic bone graft that, when preabsorbed with 400-ng rhBMP-2/7, facilitated the functional repair of critical-size rat femoral defects. Recently, we showed that pHEMA-nHA effectively retains/releases vancomycin and rhBMP-2 in vitro. The success of such a strategy requires that the incorporation of vancomycin does not compromise the structural integrity of the graft nor its ability to promote bone healing.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 41 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 21%
Researcher 7 17%
Student > Master 7 17%
Student > Doctoral Student 3 7%
Other 2 5%
Other 6 14%
Unknown 8 19%
Readers by discipline Count As %
Medicine and Dentistry 14 33%
Engineering 4 10%
Agricultural and Biological Sciences 4 10%
Psychology 2 5%
Materials Science 2 5%
Other 5 12%
Unknown 11 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2015.
All research outputs
#8,527,286
of 14,715,019 outputs
Outputs from Clinical Orthopaedics & Related Research
#3,929
of 5,698 outputs
Outputs of similar age
#93,650
of 211,862 outputs
Outputs of similar age from Clinical Orthopaedics & Related Research
#50
of 119 outputs
Altmetric has tracked 14,715,019 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,698 research outputs from this source. They receive a mean Attention Score of 4.6. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 211,862 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 119 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.