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Tetramer guided, cell sorter assisted production of clinical grade autologous NY-ESO-1 specific CD8+ T cells

Overview of attention for article published in Journal for Immunotherapy of Cancer, October 2014
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Citations

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70 Mendeley
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Title
Tetramer guided, cell sorter assisted production of clinical grade autologous NY-ESO-1 specific CD8+ T cells
Published in
Journal for Immunotherapy of Cancer, October 2014
DOI 10.1186/s40425-014-0036-y
Pubmed ID
Authors

Seth M Pollack, Robin L Jones, Erik A Farrar, Ivy P Lai, Sylvia M Lee, Jianhong Cao, Venu G Pillarisetty, Benjamin L Hoch, Ashley Gullett, Marie Bleakley, Ernest U Conrad, Janet F Eary, Kendall C Shibuya, Edus H Warren, Jason N Carstens, Shelly Heimfeld, Stanley R Riddell, Cassian Yee

Abstract

Adoptive T cell therapy represents an attractive modality for the treatment of patients with cancer. Peripheral blood mononuclear cells have been used as a source of antigen specific T cells but the very low frequency of T cells recognizing commonly expressed antigens such as NY-ESO-1 limit the applicability of this approach to other solid tumors. To overcome this, we tested a strategy combining IL-21 modulation during in vitro stimulation with first-in-class use of tetramer-guided cell sorting to generate NY-ESO-1 specific cytotoxic T lymphocytes (CTL).

Mendeley readers

The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Netherlands 1 1%
Germany 1 1%
Unknown 67 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 27%
Student > Ph. D. Student 11 16%
Student > Master 10 14%
Other 7 10%
Student > Doctoral Student 5 7%
Other 11 16%
Unknown 7 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 23%
Medicine and Dentistry 13 19%
Immunology and Microbiology 13 19%
Biochemistry, Genetics and Molecular Biology 8 11%
Engineering 6 9%
Other 5 7%
Unknown 9 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 November 2014.
All research outputs
#11,059,079
of 12,440,396 outputs
Outputs from Journal for Immunotherapy of Cancer
#579
of 594 outputs
Outputs of similar age
#175,793
of 215,217 outputs
Outputs of similar age from Journal for Immunotherapy of Cancer
#15
of 17 outputs
Altmetric has tracked 12,440,396 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 594 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 215,217 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.