Title |
Tetramer guided, cell sorter assisted production of clinical grade autologous NY-ESO-1 specific CD8+ T cells
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Published in |
Journal for Immunotherapy of Cancer, October 2014
|
DOI | 10.1186/s40425-014-0036-y |
Pubmed ID | |
Authors |
Seth M Pollack, Robin L Jones, Erik A Farrar, Ivy P Lai, Sylvia M Lee, Jianhong Cao, Venu G Pillarisetty, Benjamin L Hoch, Ashley Gullett, Marie Bleakley, Ernest U Conrad, Janet F Eary, Kendall C Shibuya, Edus H Warren, Jason N Carstens, Shelly Heimfeld, Stanley R Riddell, Cassian Yee |
Abstract |
Adoptive T cell therapy represents an attractive modality for the treatment of patients with cancer. Peripheral blood mononuclear cells have been used as a source of antigen specific T cells but the very low frequency of T cells recognizing commonly expressed antigens such as NY-ESO-1 limit the applicability of this approach to other solid tumors. To overcome this, we tested a strategy combining IL-21 modulation during in vitro stimulation with first-in-class use of tetramer-guided cell sorting to generate NY-ESO-1 specific cytotoxic T lymphocytes (CTL). |
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Geographical breakdown
Country | Count | As % |
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India | 1 | 50% |
United States | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 1% |
Netherlands | 1 | 1% |
Germany | 1 | 1% |
Unknown | 87 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 21 | 23% |
Student > Ph. D. Student | 13 | 14% |
Other | 10 | 11% |
Student > Master | 10 | 11% |
Student > Bachelor | 8 | 9% |
Other | 12 | 13% |
Unknown | 16 | 18% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 17 | 19% |
Medicine and Dentistry | 16 | 18% |
Immunology and Microbiology | 16 | 18% |
Biochemistry, Genetics and Molecular Biology | 11 | 12% |
Engineering | 5 | 6% |
Other | 6 | 7% |
Unknown | 19 | 21% |