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Minimal change disease and focal segmental glomerulosclerosis in adults: response to steroids and risk of renal failure

Overview of attention for article published in Jornal Brasileiro de Nefrologia, January 2015
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Title
Minimal change disease and focal segmental glomerulosclerosis in adults: response to steroids and risk of renal failure
Published in
Jornal Brasileiro de Nefrologia, January 2015
DOI 10.5935/0101-2800.20150075
Pubmed ID
Authors

Lúcio R. R. Moura, Marcello F. Franco, Gianna Mastroianni Kirsztajn

Abstract

There is scarce data on the clinical profile of adult Brazilian patients with nephrotic syndrome caused by minimal change disease (MCD) and focal segmental glomerulosclerosis. We evaluated the clinical characteristics and response to treatment in adult patients with nephrotic syndrome having a histological diagnosis of MCD or FSGS. This is a retrospective analysis of 50 patients with MCD and 120 with FSGS. All patients were initially treated with steroids. The study outcomes were: steroid responsiveness, prevalence of total remission, progression to chronic renal failure and need of renal replacement therapy due to end-stage renal disease (ESRD). Initial serum creatinine level was 24% higher among patients with FSGS (p = 0.02), and proteinuria levels were 36% higher in MCD (p < 0.001). Patients with MCD were sensitive to steroid therapy in 80% of the cases, with total remission in 74%, while patients with FSGS were sensitive in 58% (p = 0.01), with total remission in 30% (p = 0.002). Patients with FSGS had an acute renal failure prevalence of 39% (vs. 12%, p = 0.013) and ESRD of 10% (vs. 0%, p < 0.001). Steroid responsiveness reduced in 83% the risk of ESRD (p < 0.001), while total remission was associated to a reduction in risk of 89% (p < 0.001). A positive response to steroid therapy was the most important factor related with preservation of renal function and FSGS was related with less steroid responsiveness.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 11 32%
Student > Master 5 15%
Other 4 12%
Student > Postgraduate 3 9%
Researcher 2 6%
Other 3 9%
Unknown 6 18%
Readers by discipline Count As %
Medicine and Dentistry 17 50%
Pharmacology, Toxicology and Pharmaceutical Science 3 9%
Biochemistry, Genetics and Molecular Biology 2 6%
Nursing and Health Professions 2 6%
Agricultural and Biological Sciences 1 3%
Other 4 12%
Unknown 5 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 October 2017.
All research outputs
#8,030,802
of 12,801,103 outputs
Outputs from Jornal Brasileiro de Nefrologia
#20
of 49 outputs
Outputs of similar age
#180,272
of 313,890 outputs
Outputs of similar age from Jornal Brasileiro de Nefrologia
#1
of 1 outputs
Altmetric has tracked 12,801,103 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 49 research outputs from this source. They receive a mean Attention Score of 2.4. This one scored the same or higher as 29 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,890 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them