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X Demographics
Mendeley readers
Attention Score in Context
| Title |
FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis
|
|---|---|
| Published in |
Oncogene, October 2017
|
| DOI | 10.1038/onc.2017.358 |
| Pubmed ID | |
| Authors |
M S Chattaragada, C Riganti, M Sassoe, M Principe, M M Santamorena, C Roux, C Curcio, A Evangelista, P Allavena, R Salvia, B Rusev, A Scarpa, P Cappello, F Novelli |
| Abstract |
Mitochondrial dysregulation plays a central role in cancers and drives reactive oxygen species (ROS)-dependent tumor progression. We investigated the pro-tumoral roles of mitochondrial dynamics and altered intracellular ROS levels in pancreatic ductal adenocarcinoma (PDAC). We identified 'family with sequence similarity 49 member B' (FAM49B) as a mitochondria-localized protein that regulates mitochondrial fission and cancer progression. Silencing FAM49B in PDAC cells resulted in increased fission and mitochondrial ROS generation, which enhanced PDAC cell proliferation and invasion. Notably, FAM49B expression levels in PDAC cells were downregulated by the tumor microenvironment. Overall, the results of this study show that FAM49B acts as a suppressor of cancer cell proliferation and invasion in PDAC by regulating tumor mitochondrial redox reactions and metabolism.Oncogene advance online publication, 23 October 2017; doi:10.1038/onc.2017.358. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 63 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 19% |
| Student > Bachelor | 11 | 17% |
| Researcher | 8 | 13% |
| Student > Master | 8 | 13% |
| Student > Postgraduate | 5 | 8% |
| Other | 8 | 13% |
| Unknown | 11 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 31 | 49% |
| Medicine and Dentistry | 9 | 14% |
| Agricultural and Biological Sciences | 5 | 8% |
| Immunology and Microbiology | 2 | 3% |
| Environmental Science | 1 | 2% |
| Other | 2 | 3% |
| Unknown | 13 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 October 2018.
All research outputs
#13,220,095
of 23,006,268 outputs
Outputs from Oncogene
#8,175
of 10,676 outputs
Outputs of similar age
#157,910
of 327,882 outputs
Outputs of similar age from Oncogene
#41
of 80 outputs
Altmetric has tracked 23,006,268 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,676 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,882 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 80 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.