| Chapter title |
DNA Replication Fidelity in the Mycobacterium tuberculosis Complex. - PubMed - NCBI
|
|---|---|
| Chapter number | 13 |
| Book title |
Strain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control
|
| Published in |
Advances in experimental medicine and biology, January 2017
|
| DOI | 10.1007/978-3-319-64371-7_13 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-964369-4, 978-3-31-964371-7
|
| Authors |
Warner, Digby F, Rock, Jeremy M, Fortune, Sarah M, Mizrahi, Valerie, Digby F. Warner, Jeremy M. Rock, Sarah M. Fortune, Valerie Mizrahi |
| Abstract |
Mycobacterium tuberculosis is genetically isolated, with no evidence for horizontal gene transfer or the acquisition of episomal genetic information in the modern evolution of strains of the Mycobacterium tuberculosis complex. When considered in the context of the specific features of the disease M. tuberculosis causes (e.g., transmission via cough aerosol, replication within professional phagocytes, subclinical persistence, and stimulation of a destructive immune pathology), this implies that to understand the mechanisms ensuring preservation of genomic integrity in infecting mycobacterial populations is to understand the source of genetic variation, including the emergence of microdiverse sub-populations that may be linked to the acquisition of drug resistance. In this chapter, we focus on mechanisms involved in maintaining DNA replication fidelity in M. tuberculosis, and consider the potential to target components of the DNA replication machinery as part of novel therapeutic regimens designed to curb the emerging threat of drug-resistance. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 46 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor | 5 | 11% |
| Researcher | 5 | 11% |
| Student > Doctoral Student | 4 | 9% |
| Student > Ph. D. Student | 4 | 9% |
| Other | 3 | 7% |
| Other | 5 | 11% |
| Unknown | 20 | 43% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 4 | 9% |
| Medicine and Dentistry | 4 | 9% |
| Biochemistry, Genetics and Molecular Biology | 4 | 9% |
| Agricultural and Biological Sciences | 3 | 7% |
| Veterinary Science and Veterinary Medicine | 2 | 4% |
| Other | 6 | 13% |
| Unknown | 23 | 50% |