Title |
Mesenchymal stem cells for cardiac repair: are the actors ready for the clinical scenario?
|
---|---|
Published in |
Stem Cell Research & Therapy, October 2017
|
DOI | 10.1186/s13287-017-0695-y |
Pubmed ID | |
Authors |
Santiago Roura, Carolina Gálvez-Montón, Clémentine Mirabel, Joaquim Vives, Antoni Bayes-Genis |
Abstract |
For years, sufficient progress has been made in treating heart failure following myocardial infarction; however, the social and economic burdens and the costs to world health systems remain high. Moreover, treatment advances have not resolved the underlying problem of functional heart tissue loss. In this field of research, for years we have actively explored innovative biotherapies for cardiac repair. Here, we present a general, critical overview of our experience in using mesenchymal stem cells, derived from cardiac adipose tissue and umbilical cord blood, in a variety of cell therapy and tissue engineering approaches. We also include the latest advances and future challenges, including good manufacturing practice and regulatory issues. Finally, we evaluate whether recent approaches hold potential for reliable translation to clinical trials. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 33% |
United States | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 88 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 15 | 17% |
Student > Bachelor | 15 | 17% |
Researcher | 10 | 11% |
Student > Doctoral Student | 8 | 9% |
Student > Postgraduate | 7 | 8% |
Other | 11 | 13% |
Unknown | 22 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 24 | 27% |
Biochemistry, Genetics and Molecular Biology | 16 | 18% |
Engineering | 6 | 7% |
Agricultural and Biological Sciences | 6 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
Other | 8 | 9% |
Unknown | 26 | 30% |