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Isocitrate dehydrogenases in physiology and cancer: biochemical and molecular insight

Overview of attention for article published in Cell & Bioscience, August 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (52nd percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

Mentioned by

twitter
2 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
19 Dimensions

Readers on

mendeley
68 Mendeley
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Title
Isocitrate dehydrogenases in physiology and cancer: biochemical and molecular insight
Published in
Cell & Bioscience, August 2017
DOI 10.1186/s13578-017-0165-3
Pubmed ID
Authors

Hamoud Al-Khallaf

Abstract

Isocitrate dehydrogenases play important roles in cellular metabolism and cancer. This review will discuss how the roles of isoforms 1 and 2 in normal cell and cancer metabolism are distinct from those of isoform 3. It will also explain why, unlike 1 and 2, mutations in isoform 3 in tumor are not likely to be driver ones. A model explaining two important features of isocitrate dehydrogenases 1 and 2 mutations, their dominant negative effect and their mutual exclusivity, will be provided. The importance of targeting these mutations and the possibility of augmenting such therapy by targeting other cancer-related pathways will also be discussed.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 68 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 22%
Student > Bachelor 13 19%
Student > Master 13 19%
Researcher 11 16%
Student > Doctoral Student 3 4%
Other 5 7%
Unknown 8 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 22 32%
Agricultural and Biological Sciences 12 18%
Medicine and Dentistry 9 13%
Neuroscience 4 6%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 6 9%
Unknown 13 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2017.
All research outputs
#6,806,840
of 12,109,122 outputs
Outputs from Cell & Bioscience
#70
of 248 outputs
Outputs of similar age
#129,025
of 284,652 outputs
Outputs of similar age from Cell & Bioscience
#7
of 29 outputs
Altmetric has tracked 12,109,122 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 248 research outputs from this source. They receive a mean Attention Score of 2.3. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,652 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.