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Expression, function, and regulation of the testis-enriched heat shock HSPA2 gene in rodents and humans

Overview of attention for article published in Cell Stress and Chaperones, October 2014
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  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

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Title
Expression, function, and regulation of the testis-enriched heat shock HSPA2 gene in rodents and humans
Published in
Cell Stress and Chaperones, October 2014
DOI 10.1007/s12192-014-0548-x
Pubmed ID
Authors

Dorota Scieglinska, Zdzislaw Krawczyk

Abstract

The HSPA2 gene is a poorly characterized member of the HSPA (HSP70) family. HSPA2 was originally described as testis-specific and expressed at the highest level in pachytene spermatocytes of rodents, the expression of which is not induced by heat shock. HSPA2 is crucial for male fertility. However, recent advances have shown that HSPA2 is expressed in various tumors and in certain types of somatic tissues. In this review, we summarize the current knowledge on the HSPA2 expression pattern, including information on transcriptional, translational, posttranslational, and epigenetic mechanisms which regulate HSPA2 expression. We also present and discuss the current views concerning the functions of the HSPA2 protein in spermatogenetic, somatic, and cancer cells. The knowledge of the properties of HSPA2, although limited, shows this protein as a unique member of the HSPA family. However, understanding whether this protein could become a relevant cancer biomarker or a therapeutically applicable target requires extensive further studies.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 2%
Denmark 1 2%
Unknown 46 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 23%
Researcher 7 15%
Student > Ph. D. Student 6 13%
Student > Bachelor 5 10%
Student > Doctoral Student 3 6%
Other 9 19%
Unknown 7 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 18 38%
Agricultural and Biological Sciences 8 17%
Medicine and Dentistry 4 8%
Unspecified 1 2%
Veterinary Science and Veterinary Medicine 1 2%
Other 7 15%
Unknown 9 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 November 2015.
All research outputs
#20,656,161
of 25,373,627 outputs
Outputs from Cell Stress and Chaperones
#494
of 698 outputs
Outputs of similar age
#200,182
of 273,492 outputs
Outputs of similar age from Cell Stress and Chaperones
#5
of 11 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 698 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,492 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.